TY - JOUR
T1 - Downstaging of hepatocellular carcinoma prior to liver transplant
T2 - Is there a role for adjuvant sorafenib in locoregional therapy?
AU - Vagefi, Parsia A.
AU - Hirose, Ryutaro
PY - 2010/12
Y1 - 2010/12
N2 - Hepatocellular carcinoma (HCC) remains a common cause of mortality worldwide. Liver transplantation has emerged as the optimal treatment for cirrhotic patients with HCC; however, the shortage of donor organs leaves waitlisted patients at risk for disease progression beyond transplant criteria. Prevention of waitlist dropout has fueled investigation into a wide array of locoregional therapies for the management of HCC in candidates awaiting liver transplantation. We present a patient with HCC who underwent treatment with sorafenib, which resulted in a remarkable reduction in tumor burden to allow for liver transplant listing.
AB - Hepatocellular carcinoma (HCC) remains a common cause of mortality worldwide. Liver transplantation has emerged as the optimal treatment for cirrhotic patients with HCC; however, the shortage of donor organs leaves waitlisted patients at risk for disease progression beyond transplant criteria. Prevention of waitlist dropout has fueled investigation into a wide array of locoregional therapies for the management of HCC in candidates awaiting liver transplantation. We present a patient with HCC who underwent treatment with sorafenib, which resulted in a remarkable reduction in tumor burden to allow for liver transplant listing.
KW - hepatocellular cancer
KW - liver transplantation
KW - locoregional therapy
KW - sorafenib
UR - http://www.scopus.com/inward/record.url?scp=78649718618&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78649718618&partnerID=8YFLogxK
U2 - 10.1007/s12029-010-9163-y
DO - 10.1007/s12029-010-9163-y
M3 - Review article
C2 - 20443078
AN - SCOPUS:78649718618
SN - 1941-6628
VL - 41
SP - 217
EP - 220
JO - Journal of Gastrointestinal Cancer
JF - Journal of Gastrointestinal Cancer
IS - 4
ER -