Dose-dependency and rate of decay of efficacy of resovist on MR images in a rat cirrhotic liver model

Naoki Kato, Masaya Takahashi, Takashi Tsuji, Shinya Ihara, Matthias Brautigam, Tomoaki Miyazawa

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


RATIONALE AND OBJECTIVES. To investigate the dose-dependency and half- life of decay of the signal reduction by superparamagnetic iron oxides on three different spin-echo images in a rat model of cirrhosis. METHODS. For normal and cirrhotic liver, signal intensities were measured 15 minutes after injection of Resovist (range, 1-40 μmol Fe/kg) on three different spin-echo images. Subsequently, recovery of signal intensity was monitored up to 2 weeks after injection. RESULTS. The dose-dependency of efficacy was somewhat less at all doses and imaging parameters in cirrhotic liver. However, the submaximal effect was obtained at a dose of 20 μmol Fe/kg, the same as in normal liver. The rate of decay of the efficacy in cirrhotic liver was similar to or faster than that in normal liver. CONCLUSIONS. The dose- dependency and rate of decay of efficacy of Resovist in cirrhosis were similar to those in normal liver, although the efficacy was less in cirrhotic liver and both the dose-dependency and rate of decay of efficacy were dependent on imaging parameters.

Original languageEnglish (US)
Pages (from-to)551-557
Number of pages7
JournalInvestigative Radiology
Issue number9
StatePublished - Sep 1999


  • Cirrhosis
  • Contrast agent
  • Magnetic resonance
  • Rats
  • Resovist

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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