| Original language | English (US) |
|---|---|
| Pages (from-to) | 265-272 |
| Number of pages | 8 |
| Journal | Brain Research |
| Volume | 191 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jun 2 1980 |
Keywords
- fearlike aversion
- periaqueductal gray
- serotonin
ASJC Scopus subject areas
- Neuroscience(all)
- Molecular Biology
- Clinical Neurology
- Developmental Biology
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In: Brain Research, Vol. 191, No. 1, 02.06.1980, p. 265-272.
Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Dorsal raphe nucleus stimulation reduces centrally-elicited fearlike behavior
AU - Sanford Kiser, R.
AU - Brown, Cora A.
AU - Sanghera, Manjit K.
AU - German, Dwight C.
N1 - Funding Information: neurons. Stimulation of certain brain sites, rostral to the DRN stimulation sites of this study, have been found to elevate the levels of enkephalin-like and/or fi-endorphin-like material in the cerebrospinal fluid and to produce analgesia4,16. The analgesia produced by opiates is known to primarily involve a reduction in the aversive affective components of protopathic pain sensation is, which include fear, apprehension and similar affective sensations produced by PAG stimulation in man. Hence, it is possible that the reduction of dorsal PAG stimulation-produced fearlike behavior resulting in this study from stimulation of the DRN area reflects an increased release of opiate-like materials. A lag time occurred before the 'anti-aversive' effects of DRN stimulation developed in the present study, and these effects outlasted the time of actual DRN stimulation. This time course suggests a neurohumoral process. Perhaps DRN stimulation releases 5-HT from the periventricular 5-HT plexus t,s,~a,3a or opiate-like materials from periventricular fl-endorphin and/or enkephalin axons 7.14,36,4° into the cerebrospinal fluid to be transported as a neurohumor to target sites along the ventricular walls. In light of reports that brain stimulation sites which elicit fearlike behavior have a periventricular distribution 1°,13,29,34,37, 5-HT or opiate-like materials released by DRN stimulation into the cerebrospinal fluid in this fashion could potentially regulate aversive affective processes in a large mass of periventricular brain tissue. Clarifying the relative roles of 5-HT and opiate-like compounds in the 'anti-aversive' effects of DRN stimulation may prove difficult, since 5-HT appears to be closely involved in the actions of opiates and endorphins15,24,27,3L We thank Margaret Mendershausen and Elaine Vogel for assistance in this study. Supported by NIMH Grant MH-26032, NIH General Research Support Grant 5-501-RR05426-11 and -13, and NIH Biomedical Research Support Grants 5-501-RR05426-12 and -15.
PY - 1980/6/2
Y1 - 1980/6/2
KW - fearlike aversion
KW - periaqueductal gray
KW - serotonin
UR - http://www.scopus.com/inward/record.url?scp=0019154182&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019154182&partnerID=8YFLogxK
U2 - 10.1016/0006-8993(80)90331-5
DO - 10.1016/0006-8993(80)90331-5
M3 - Article
C2 - 7378757
AN - SCOPUS:0019154182
SN - 0006-8993
VL - 191
SP - 265
EP - 272
JO - Brain Research
JF - Brain Research
IS - 1
ER -