Dominant oncogenes and tumor suppressor genes in the pathogenesis of lung cancer.

J. Viallet, J. D. Minna

Research output: Contribution to journalReview articlepeer-review

64 Scopus citations


An understanding of the molecular pathogenesis of lung cancer has evolved from classic cytogenetic studies and the use of restriction fragment length polymorphisms to encompass the definition of specific genetic abnormalities associated with this disease. Activation of the dominant class of oncogenes is frequent, with involvement of the ras and myc families of genes being the best defined. Several examples of inactivation at specific loci exist and have been related to the presence of tumor suppressor genes, most notably the retinoblastoma gene, p53, and a putative gene located on the short arm of chromosome 3. As our understanding of the nature and interactions between these numerous genetic events evolves, new opportunities for early diagnosis, prevention, and treatment will arise.

Original languageEnglish (US)
Pages (from-to)225-232
Number of pages8
JournalAmerican journal of respiratory cell and molecular biology
Issue number3
StatePublished - Mar 1990

ASJC Scopus subject areas

  • Molecular Biology
  • Pulmonary and Respiratory Medicine
  • Clinical Biochemistry
  • Cell Biology


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