TY - JOUR
T1 - Does earlier lobectomy result in better long-term pulmonary function in children with congenital lung anomalies?
T2 - A prospective study
AU - Naito, Yoko
AU - Beres, Alana
AU - Lapidus-Krol, Eveline
AU - Ratjen, Felix
AU - Langer, Jacob C.
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2012/5
Y1 - 2012/5
N2 - Background: Management of asymptomatic congenital pulmonary airway malformations remains controversial when addressing the optimal timing of surgical resection. Neonatal resection is advocated by some based on the theory that earlier lobectomy results in greater compensatory lung growth. We examined whether age at lobectomy is correlated with better pulmonary outcomes as reflected by pulmonary function and exercise testing. Methods: Patients who had lobectomy for congenital pulmonary airway malformation between 1985 and 2002 were identified and underwent detailed clinical history, physical examination, pulmonary function testing (total lung capacity, forced vital capacity, forced expiratory volume in 1 second), and exercise testing (power, maximal oxygen uptake [Vo 2max]). Results: Of 87 patients identified, 47 met the inclusion criteria, and 28 were tested prospectively. Age at the time of lobectomy ranged from 3 days to 56 months. There was no correlation between age at lobectomy and pulmonary function (total lung capacity, P =.408; forced vital capacity, P =.319; forced expiratory volume in 1 second, P =.174) or maximal work capacity (power, P =.280). There was a trend toward lower Vo 2max in patients who had undergone lobectomy at an older age (Vo 2max, P =.055). Conclusion: Most children undergoing lobectomy have normal long-term pulmonary function. We found no correlation between age at lobectomy and future pulmonary function. Cardiopulmonary exercise testing should be considered in evaluating functional outcome in these patients.
AB - Background: Management of asymptomatic congenital pulmonary airway malformations remains controversial when addressing the optimal timing of surgical resection. Neonatal resection is advocated by some based on the theory that earlier lobectomy results in greater compensatory lung growth. We examined whether age at lobectomy is correlated with better pulmonary outcomes as reflected by pulmonary function and exercise testing. Methods: Patients who had lobectomy for congenital pulmonary airway malformation between 1985 and 2002 were identified and underwent detailed clinical history, physical examination, pulmonary function testing (total lung capacity, forced vital capacity, forced expiratory volume in 1 second), and exercise testing (power, maximal oxygen uptake [Vo 2max]). Results: Of 87 patients identified, 47 met the inclusion criteria, and 28 were tested prospectively. Age at the time of lobectomy ranged from 3 days to 56 months. There was no correlation between age at lobectomy and pulmonary function (total lung capacity, P =.408; forced vital capacity, P =.319; forced expiratory volume in 1 second, P =.174) or maximal work capacity (power, P =.280). There was a trend toward lower Vo 2max in patients who had undergone lobectomy at an older age (Vo 2max, P =.055). Conclusion: Most children undergoing lobectomy have normal long-term pulmonary function. We found no correlation between age at lobectomy and future pulmonary function. Cardiopulmonary exercise testing should be considered in evaluating functional outcome in these patients.
KW - Cardiopulmonary exercise test
KW - Congenital pulmonary airway malformation
KW - Lobectomy
KW - Pulmonary function test
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U2 - 10.1016/j.jpedsurg.2012.01.037
DO - 10.1016/j.jpedsurg.2012.01.037
M3 - Article
C2 - 22595560
AN - SCOPUS:84861122734
SN - 0022-3468
VL - 47
SP - 852
EP - 856
JO - Journal of Pediatric Surgery
JF - Journal of Pediatric Surgery
IS - 5
ER -