Do symbiotic bacteria subvert host immunity?

Research output: Contribution to journalArticlepeer-review

163 Scopus citations


The mammalian intestine is home to dense and complex indigenous bacterial communities. Most of these bacteria establish beneficial symbiotic relationships with their hosts, making important contributions to host metabolism and digestive efficiency. The vast numbers of intestinal bacteria and their proximity to host tissues raise the question of how symbiotic host-bacterial relationships are established without eliciting potentially harmful immune responses. In light of the varied ways in which pathogenic bacteria manipulate host immunity, this Opinion article explores the role of immune suppression, subversion and evasion in the establishment of symbiotic host-bacterial associations.

Original languageEnglish (US)
Pages (from-to)367-374
Number of pages8
JournalNature Reviews Microbiology
Issue number5
StatePublished - 2009

ASJC Scopus subject areas

  • Microbiology
  • Immunology and Microbiology(all)
  • Infectious Diseases


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