DNA-PKcs inhibition impairs HDAC6-mediated HSP90 chaperone function on Aurora A and enhances HDACs inhibitor-induced cell killing by increasing mitotic aberrant spindle assembly

Medicine & Life Sciences

• DNA-Activated Protein Kinase 100%
• Spindle Apparatus 84%
• Histone Deacetylase Inhibitors 80%
• Catalytic Domain 61%
• Histone Deacetylases 31%
• Phosphotransferases 10%
• Acetylesterase 10%
• Catalytic DNA 10%
• 1,2-di-(4-sulfamidophenyl)-4-butylpyrazolidine-3,5-dione 9%
• Ataxia Telangiectasia 8%
• Centrosome 8%
• Double-Stranded DNA Breaks 7%
• Second Primary Neoplasms 7%
• Mitosis 6%
• Neoplasms 6%
• DNA Repair 6%
• DNA Damage 5%
• Cell Death 5%
• In Vitro Techniques 3%
• Therapeutics 2%