Diversity of Polyubiquitin Chains

Anirban Adhikari, Zhijian J. Chen

Research output: Contribution to journalShort surveypeer-review

57 Scopus citations


Polyubiquitin chains linked through different lysines of ubiquitin may exert both proteasome-dependent and -independent functions. In a recent Cell issue, Xu et al. employ quantitative proteomics to profile polyubiquitin linkages in yeast. They find that linkages through all lysines of ubiquitin, except lysine-63, can target proteasomal degradation in vivo, and that lysine-11 polyubiquitination is important for endoplasmic reticulum-associated degradation (ERAD).

Original languageEnglish (US)
Pages (from-to)485-486
Number of pages2
JournalDevelopmental cell
Issue number4
StatePublished - Apr 21 2009

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology


Dive into the research topics of 'Diversity of Polyubiquitin Chains'. Together they form a unique fingerprint.

Cite this