Distribution of model-based multipoint heterogeneity lod scores

Chao Xing, Nathan Morris, Guan Xing

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The distribution of two-point heterogeneity lod scores (HLOD) has been intensively investigated because the conventional χ2 approximation to the likelihood ratio test is not directly applicable. However, there was no study investigating the distribution of the multipoint HLOD despite its wide application. Here we want to point out that, compared with the two-point HLOD, the multipoint HLOD essentially tests for homogeneity given linkage and follows a relatively simple limiting distribution , which can be obtained by established statistical theory. We further examine the theoretical result by simulation studies.

Original languageEnglish (US)
Pages (from-to)912-916
Number of pages5
JournalGenetic Epidemiology
Issue number8
StatePublished - Dec 2010


  • Distribution
  • Heterogeneity lod score
  • Multipoint

ASJC Scopus subject areas

  • Epidemiology
  • Genetics(clinical)


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