@inproceedings{891b86b69f2240d1bdb5822736dfc32a,
title = "Distal renal tubular acidosis and calcium nephrolithiasis",
abstract = "Calcium stones are commonly encountered in patients with congenital distal renal tubular acidosis, a disease of renal acidification caused by mutations in either the vacuolar H+ATPase (B1 or a4 subunit), anion exchanger-1, or carbonic anhydrase II. Based on the existing database, we present two hypotheses. First, heterozygotes with mutations in Bl subunit of H+-ATPase are not normal but may harbor biochemical abnormalities such as renal acidification defects, hypercalciuria, and hypocitraturia which can predispose them to kidney stone formation Second, we propose at least two mechanisms by which mutant B1 subunit can impair H+-ATPase: defective pump assembly and defective pump activity.",
keywords = "Anion exchanger, Carbonic anhydrase, Membrane transport, Proton ATPase",
author = "Moe, {Orson W.} and Fuster, {Daniel G.} and Xie, {Xiao Song}",
year = "2008",
doi = "10.1063/1.2998065",
language = "English (US)",
isbn = "9780735405776",
series = "AIP Conference Proceedings",
pages = "81--97",
booktitle = "Renal Stone Disease 2 - 2nd International Urolithiasis Research Symposium",
note = "2nd International Urolithiasis Research Symposium ; Conference date: 17-04-2008 Through 18-04-2008",
}