Dissecting the impact of depression on decision-making

Victoria M. Lawlor, Christian A. Webb, Thomas V. Wiecki, Michael J. Frank, Madhukar Trivedi, Diego A. Pizzagalli, Daniel G. Dillon

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Background Cognitive deficits in depressed adults may reflect impaired decision-making. To investigate this possibility, we analyzed data from unmedicated adults with Major Depressive Disorder (MDD) and healthy controls as they performed a probabilistic reward task. The Hierarchical Drift Diffusion Model (HDDM) was used to quantify decision-making mechanisms recruited by the task, to determine if any such mechanism was disrupted by depression.Methods Data came from two samples (Study 1: 258 MDD, 36 controls; Study 2: 23 MDD, 25 controls). On each trial, participants indicated which of two similar stimuli was presented; correct identifications were rewarded. Quantile-probability plots and the HDDM quantified the impact of MDD on response times (RT), speed of evidence accumulation (drift rate), and the width of decision thresholds, among other parameters.Results RTs were more positively skewed in depressed v. healthy adults, and the HDDM revealed that drift rates were reduced - and decision thresholds were wider - in the MDD groups. This pattern suggests that depressed adults accumulated the evidence needed to make decisions more slowly than controls did.Conclusions Depressed adults responded slower than controls in both studies, and poorer performance led the MDD group to receive fewer rewards than controls in Study 1. These results did not reflect a sensorimotor deficit but were instead due to sluggish evidence accumulation. Thus, slowed decision-making - not slowed perception or response execution - caused the performance deficit in MDD. If these results generalize to other tasks, they may help explain the broad cognitive deficits seen in depression.

Original languageEnglish (US)
Pages (from-to)1613-1622
Number of pages10
JournalPsychological Medicine
Issue number10
StatePublished - Jul 1 2020


  • Computational modeling
  • decision-making
  • depression
  • drift diffusion model
  • reward

ASJC Scopus subject areas

  • Applied Psychology
  • Psychiatry and Mental health


Dive into the research topics of 'Dissecting the impact of depression on decision-making'. Together they form a unique fingerprint.

Cite this