Disruption of signaling by yersinia effector YopJ, a ubiquitin-like protein protease

K. Orth, Z. Xu, M. B. Mudgett, Z. Q. Bao, L. E. Palmer, J. B. Bliska, W. F. Mangel, B. Staskawicz, J. E. Dixon

Research output: Contribution to journalArticlepeer-review

445 Scopus citations


Homologs of the Yersinia virulence effector YopJ are found in both plant and animal bacterial pathogens, as well as plant symbionts. These YopJ family members were shown to act as cysteine proteases. The catalytic triad of the protease was required for inhibition of the mitogen-activated protein kinase (MAPK) and nuclear factor κB (NF-κB) signaling in animal cells and for induction of LocaLized ceLL death in plants. The substrates for YopJ were shown to be highly conserved ubiquitin-Like moLecuLes, which are covalently added to numerous regulatory proteins. YopJ family members exert their pathogenic effect on ceLLs by disrupting this posttranslational modification.

Original languageEnglish (US)
Pages (from-to)1594-1597
Number of pages4
Issue number5496
StatePublished - Nov 24 2000

ASJC Scopus subject areas

  • General


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