Disease model: Human aging

Makoto Kuro-o

Research output: Contribution to journalReview articlepeer-review

61 Scopus citations


Very little is known about the molecular mechanisms of human aging. This, at least in part, derives from a paucity of appropriate animal models of aging. Until recently, the senescence-accelerated mouse was the only mammalian model of aging. However, novel mouse models that exhibit multiple aging phenotypes have been developed in the past few years by disruption of the klotho gene, the telomerase gene and the genes involved in premature aging syndromes. These mouse models are expected to be important tools for aging research.

Original languageEnglish (US)
Pages (from-to)179-181
Number of pages3
JournalTrends in Molecular Medicine
Issue number4
StatePublished - 2001

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology


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