TY - JOUR
T1 - Disease due to Cytomegalovirus and Its Long-term Consequences in Renal Transplant Recipients
T2 - Correlation of Allograft Survival With Disease due to Cytomegalovirus and Rubella Antibody Level
AU - Luby, James P.
AU - Ware, Athol J.
AU - Hull, Alan R.
AU - Helderman, J. Harold
AU - Gailiunas, Peter
AU - Butler, Sandra
AU - Atkins, Carolyn
PY - 1983/6
Y1 - 1983/6
N2 - We prospectively studied 52 consecutive renal allograft recipients who retained their grafts at least three months. The transplant recipients were observed for five years or longer. Disease due to cytomegalovirus (CMV) occurred in nine (17.3%). Manifestations of disease due to CMV that were significantly more common than in chronologically matched controls in comparable periods after transplantation included fever, leukopenia, hepatic function abnormalities, pneumonia, and renal dysfunction. Life-table analyses suggested a trend of decreased allograft survival with disease due to CMV, but the difference between controls was not statistically significant. A significant inverse correlation were noted between the level of hemagglutination inhibition antibody to rubella virus reached after transplantation and allograft survival. This correlation remained statistically significant even when patients with disease due to CMV were excluded from the analysis.
AB - We prospectively studied 52 consecutive renal allograft recipients who retained their grafts at least three months. The transplant recipients were observed for five years or longer. Disease due to cytomegalovirus (CMV) occurred in nine (17.3%). Manifestations of disease due to CMV that were significantly more common than in chronologically matched controls in comparable periods after transplantation included fever, leukopenia, hepatic function abnormalities, pneumonia, and renal dysfunction. Life-table analyses suggested a trend of decreased allograft survival with disease due to CMV, but the difference between controls was not statistically significant. A significant inverse correlation were noted between the level of hemagglutination inhibition antibody to rubella virus reached after transplantation and allograft survival. This correlation remained statistically significant even when patients with disease due to CMV were excluded from the analysis.
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U2 - 10.1001/archinte.1983.00350060048006
DO - 10.1001/archinte.1983.00350060048006
M3 - Article
C2 - 6305295
AN - SCOPUS:84948726720
SN - 0003-9926
VL - 143
SP - 1126
EP - 1129
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
IS - 6
ER -