Discovery and Roles of ER-Endolysosomal Contact Sites in Disease

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17 Scopus citations


Inter-organelle membrane contact sites (MCSs) serve as unique microenvironments for the sensing and exchange of cellular metabolites and lipids. Though poorly defined, ER-endolysosomal contact sites are quickly becoming recognized as centers for inter-organelle lipid exchange and metabolic decision-making. Here, we review the discovery and current state of knowledge of ER-endolysosomal MCSs with particular focus on the molecular players that establish and/or utilize these contact sites in metabolism. We also discuss associations of ER-endolysosomal MCS-associated proteins in human disease, as well as the therapeutic promise these contact sites hold in modulating cellular physiology.

Original languageEnglish (US)
Pages (from-to)135-147
Number of pages13
JournalAdvances in experimental medicine and biology
StatePublished - 2017


  • Endoplasmic reticulum
  • Endosome
  • Inter-organelle
  • Lysosome
  • Membrane contact site (MCS)

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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