Direct palladium-catalyzed alkynylation of N-fused heterocycles

Ilya V. Seregin, Victoria Ryabova, Vladimir Gevorgyan

Research output: Contribution to journalArticlepeer-review

253 Scopus citations


The first example of direct C-H alkynylation of electron-rich heteroaromatics has been demonstrated. This mild, simple, and general method allows for the efficient synthesis of diverse alkynyl heterocycles. Kinetic isotope effect studies support an electrophilic substitution pathway for this transformation.

Original languageEnglish (US)
Pages (from-to)7742-7743
Number of pages2
JournalJournal of the American Chemical Society
Issue number25
StatePublished - Jun 27 2007
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry


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