Direct palladium-catalyzed alkynylation of N-fused heterocycles

Ilya V. Seregin; Victoria Ryabova; Vladimir Gevorgyan

doi:10.1021/ja072718l

Direct palladium-catalyzed alkynylation of N-fused heterocycles

Ilya V. Seregin, Victoria Ryabova, Vladimir Gevorgyan

Research output: Contribution to journal › Article › peer-review

255 Scopus citations

Abstract

The first example of direct C-H alkynylation of electron-rich heteroaromatics has been demonstrated. This mild, simple, and general method allows for the efficient synthesis of diverse alkynyl heterocycles. Kinetic isotope effect studies support an electrophilic substitution pathway for this transformation.

Original language	English (US)
Pages (from-to)	7742-7743
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	129
Issue number	25
DOIs	https://doi.org/10.1021/ja072718l
State	Published - Jun 27 2007
Externally published	Yes

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja072718l

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title = "Direct palladium-catalyzed alkynylation of N-fused heterocycles",

abstract = "The first example of direct C-H alkynylation of electron-rich heteroaromatics has been demonstrated. This mild, simple, and general method allows for the efficient synthesis of diverse alkynyl heterocycles. Kinetic isotope effect studies support an electrophilic substitution pathway for this transformation.",

author = "Seregin, {Ilya V.} and Victoria Ryabova and Vladimir Gevorgyan",

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Direct palladium-catalyzed alkynylation of N-fused heterocycles

Abstract

ASJC Scopus subject areas

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