Direct Electrophilic Silylation of Terminal Alkynes

Aleksey A. Andreev, Valeri V. Konshin, Nikolai V. Komarov, Michael Rubin, Chad Brouwer, Vladimir Gevorgyan

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


(Equation presented) A variety of alkynylsilanes were efficiently prepared via direct silylation of terminal alkynes with aminosilanes in the presence of zinc halides. Base- and nucleophile-sensitive functionalities were perfectly tolerated under the above reaction conditions. Initial mechanistic studies support the electrophilic character of this transformation.

Original languageEnglish (US)
Pages (from-to)421-424
Number of pages4
JournalOrganic Letters
Issue number3
StatePublished - Feb 5 2004
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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