TY - JOUR
T1 - Diffusion tensor imaging biomarkers for traumatic axonal injury
T2 - Analysis of three analytic methods
AU - Marquez De La Plata, Carlos D.
AU - Yang, Fanpei Gloria
AU - Wang, Jun Yi
AU - Krishnan, Kamini
AU - Bakhadirov, Khamid
AU - Paliotta, Christopher
AU - Aslan, Sina
AU - Devous, Michael D.
AU - Moore, Carol
AU - Harper, Caryn
AU - McColl, Roderick
AU - Munro Cullum, C.
AU - Diaz-Arrastia, Ramon
PY - 2011/1
Y1 - 2011/1
N2 - Traumatic axonal injury (TAI) is a common mechanism of traumatic brain injury not readily identified using conventional neuroimaging modalities. Novel imaging modalities such as diffusion tensor imaging (DTI) can detect microstructural compromise in white matter (WM) in various clinical populations including TAI. DTI-derived data can be analyzed using global methods (i.e., WM histogram or voxel-based approaches) or a regional approach (i.e., tractography). While each of these methods produce qualitatively comparable results, it is not clear which is most useful in clinical research and ultimately in clinical practice. This study compared three methods of analyzing DTI-derived data with regard to detection of WM injury and their association with clinical outcomes. Thirty patients with TAI and 19 demographically similar normal controls were scanned using a 3 Tesla magnet. Patients were scanned approximately eight months postinjury, and underwent an outcomes assessment at that time. Histogram analysis of fractional anisotropy (FA) and mean diffusivity showed global WM integrity differences between patients and controls. Voxel-based and tractography analyses showed significant decreases in FA within centroaxial structures involved in TAI. All three techniques were associated with functional and cognitive outcomes. DTI measures of microstructural integrity appear robust, as the three analysis techniques studied showed adequate utility for detecting WM injury. (JINS, 2011, 17, 24-35)
AB - Traumatic axonal injury (TAI) is a common mechanism of traumatic brain injury not readily identified using conventional neuroimaging modalities. Novel imaging modalities such as diffusion tensor imaging (DTI) can detect microstructural compromise in white matter (WM) in various clinical populations including TAI. DTI-derived data can be analyzed using global methods (i.e., WM histogram or voxel-based approaches) or a regional approach (i.e., tractography). While each of these methods produce qualitatively comparable results, it is not clear which is most useful in clinical research and ultimately in clinical practice. This study compared three methods of analyzing DTI-derived data with regard to detection of WM injury and their association with clinical outcomes. Thirty patients with TAI and 19 demographically similar normal controls were scanned using a 3 Tesla magnet. Patients were scanned approximately eight months postinjury, and underwent an outcomes assessment at that time. Histogram analysis of fractional anisotropy (FA) and mean diffusivity showed global WM integrity differences between patients and controls. Voxel-based and tractography analyses showed significant decreases in FA within centroaxial structures involved in TAI. All three techniques were associated with functional and cognitive outcomes. DTI measures of microstructural integrity appear robust, as the three analysis techniques studied showed adequate utility for detecting WM injury. (JINS, 2011, 17, 24-35)
KW - Cognitive outcomes
KW - DTI
KW - Memory
KW - TAI
KW - Tractography
KW - Traumatic Brain injury
UR - http://www.scopus.com/inward/record.url?scp=79451474245&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79451474245&partnerID=8YFLogxK
U2 - 10.1017/S1355617710001189
DO - 10.1017/S1355617710001189
M3 - Article
C2 - 21070694
AN - SCOPUS:79451474245
SN - 1355-6177
VL - 17
SP - 24
EP - 35
JO - Journal of the International Neuropsychological Society
JF - Journal of the International Neuropsychological Society
IS - 1
ER -