Differential behavioral and neurochemical effects of cocaine after early exposure to methylphenidate in an animal model of attention deficit hyperactivity disorder

Patrick N. Augustyniak; Said Kourrich; Shohreh M. Rezazadeh; Jane Stewart; Andreas Arvanitogiannis

doi:10.1016/j.bbr.2005.09.014

Differential behavioral and neurochemical effects of cocaine after early exposure to methylphenidate in an animal model of attention deficit hyperactivity disorder

Patrick N. Augustyniak, Said Kourrich, Shohreh M. Rezazadeh, Jane Stewart, Andreas Arvanitogiannis

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

We used a putative animal model of attention deficit hyperactivity disorder (ADHD), the SHR rat, to examine the effects of repeated exposure to methylphenidate (MPH; Ritalin®) during the pubertal period on cocaine-induced conditioned place preference and dopamine (DA) levels in the nucleus accumbens (NAc) in adulthood. Our results indicate that early exposure to methylphenidate diminishes sensitivity to the incentive properties of cocaine in adulthood, but it does so without altering the response of the mesolimbic dopamine system.

Original language	English (US)
Pages (from-to)	379-382
Number of pages	4
Journal	Behavioural Brain Research
Volume	167
Issue number	2
DOIs	https://doi.org/10.1016/j.bbr.2005.09.014
State	Published - Feb 28 2006

Keywords

Dopamine
In vivo microdialysis
Nucleus accumbens
Place conditioning
Psychostimulants
SHR rat

ASJC Scopus subject areas

Behavioral Neuroscience

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10.1016/j.bbr.2005.09.014

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Differential behavioral and neurochemical effects of cocaine after early exposure to methylphenidate in an animal model of attention deficit hyperactivity disorder. / Augustyniak, Patrick N.; Kourrich, Said; Rezazadeh, Shohreh M. et al.
In: Behavioural Brain Research, Vol. 167, No. 2, 28.02.2006, p. 379-382.

Research output: Contribution to journal › Article › peer-review

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abstract = "We used a putative animal model of attention deficit hyperactivity disorder (ADHD), the SHR rat, to examine the effects of repeated exposure to methylphenidate (MPH; Ritalin{\textregistered}) during the pubertal period on cocaine-induced conditioned place preference and dopamine (DA) levels in the nucleus accumbens (NAc) in adulthood. Our results indicate that early exposure to methylphenidate diminishes sensitivity to the incentive properties of cocaine in adulthood, but it does so without altering the response of the mesolimbic dopamine system.",

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AU - Stewart, Jane

AU - Arvanitogiannis, Andreas

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Differential behavioral and neurochemical effects of cocaine after early exposure to methylphenidate in an animal model of attention deficit hyperactivity disorder

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