TY - JOUR
T1 - Differential associations of diastolic and systolic pressures with cerebral measures in older individuals with mild cognitive impairment
AU - Shokouhi, Mahsa
AU - Qiu, Deqiang
AU - Tahhan, Ayman Samman
AU - Quyyumi, Arshed A.
AU - Hajjar, Ihab
N1 - Funding Information:
This work was funded by The National Institute on Aging grants #R01AG042127, AG051633, and AG057470 (to I.H.).
Publisher Copyright:
© American Journal of Hypertension, Ltd 2018. All rights reserved.
PY - 2018/11/13
Y1 - 2018/11/13
N2 - BACKGROUND Reports on the relative importance of the diastolic and systolic blood pressures (DBP and SBP) in age-related cognitive decline are mixed. Investigating the relation between DBP/SBP and functional and structural brain changes could elucidate which of the 2 measures is more critically important for brain function and, consequently, cognitive impairment. METHODS We investigated the association of SBP and DBP with cortical volume, cerebral blood flow (CBF), and white matter lesions (WML), in nondemented older adults with and without mild cognitive impairment (MCI; N = 265, 185 MCI, mean age = 64 years). Brachial blood pressure was measured twice while seated, and the average of the 2 measures was used. Cortical volume, gray matter (GM) CBF, and WML were estimated using T1-weighted imaging, arterial spin labeling, and fluid attenuation inversion recovery, respectively. RESULTS Reduced cortical volume was associated with elevated DBP (β= −0.18, P = 0.034) but not with SBP (β = −0.10, P = 0.206). GM CBF was associated with DBP (β = −0.13, P = 0.048) but not with SBP (β = −0.07, P = 0.275). Likewise, CBF within brain regions where MCI patients showed hypoperfusion were only associated with DBP (DBP: β = −0.17, P = 0.005; SBP: β = −0.09, P = 0.120). WML volume was associated with both DBP (β = 0.20, P = 0.005) and SBP (β = 0.30, P < 0.001). For all measures, there was no interaction between DBP/SBP and cognitive status, indicating that these associations were independent of the cognitive status. CONCLUSIONS Independently of the cognitive status, DBP is more critically important for GM volume and perfusion, whereas WML is associated with both blood pressures, likely reflecting long-term effect of hypertension and autoregulation dysfunction.
AB - BACKGROUND Reports on the relative importance of the diastolic and systolic blood pressures (DBP and SBP) in age-related cognitive decline are mixed. Investigating the relation between DBP/SBP and functional and structural brain changes could elucidate which of the 2 measures is more critically important for brain function and, consequently, cognitive impairment. METHODS We investigated the association of SBP and DBP with cortical volume, cerebral blood flow (CBF), and white matter lesions (WML), in nondemented older adults with and without mild cognitive impairment (MCI; N = 265, 185 MCI, mean age = 64 years). Brachial blood pressure was measured twice while seated, and the average of the 2 measures was used. Cortical volume, gray matter (GM) CBF, and WML were estimated using T1-weighted imaging, arterial spin labeling, and fluid attenuation inversion recovery, respectively. RESULTS Reduced cortical volume was associated with elevated DBP (β= −0.18, P = 0.034) but not with SBP (β = −0.10, P = 0.206). GM CBF was associated with DBP (β = −0.13, P = 0.048) but not with SBP (β = −0.07, P = 0.275). Likewise, CBF within brain regions where MCI patients showed hypoperfusion were only associated with DBP (DBP: β = −0.17, P = 0.005; SBP: β = −0.09, P = 0.120). WML volume was associated with both DBP (β = 0.20, P = 0.005) and SBP (β = 0.30, P < 0.001). For all measures, there was no interaction between DBP/SBP and cognitive status, indicating that these associations were independent of the cognitive status. CONCLUSIONS Independently of the cognitive status, DBP is more critically important for GM volume and perfusion, whereas WML is associated with both blood pressures, likely reflecting long-term effect of hypertension and autoregulation dysfunction.
KW - Arterial spin labeling
KW - Blood pressure
KW - Cerebral perfusion
KW - Hypertension
KW - Mild cognitive impairment
KW - White matter lesions
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U2 - 10.1093/ajh/hpy104
DO - 10.1093/ajh/hpy104
M3 - Article
C2 - 30052724
AN - SCOPUS:85056523154
SN - 0895-7061
VL - 31
SP - 1268
EP - 1277
JO - American Journal of Hypertension
JF - American Journal of Hypertension
IS - 12
ER -