TY - JOUR
T1 - Dietary total antioxidant capacity is inversely associated with prostate cancer aggressiveness in a population-based study
AU - Vance, Terrence M.
AU - Wang, Ying
AU - Su, L. Joseph
AU - Fontham, Elizabeth T.H.
AU - Steck, Susan E.
AU - Arab, Lenore
AU - Bensen, Jeannette T.
AU - Mohler, James L.
AU - Chen, Ming Hui
AU - Chun, Ock K.
N1 - Funding Information:
Funding This research was supported by the NIH Cancer Epidemiology Small Grant #1R03CA159421-01A1 and Department of Defense contract DAMD 17-03-2-0052. The authors thank the North Carolina Central Cancer Registry, the Louisiana Tumor Registry, and the PCaP staff, advisory committees and participants for their important contributions.
Publisher Copyright:
© 2016 Taylor & Francis Group, LLC.
PY - 2016/2/17
Y1 - 2016/2/17
N2 - The purpose of this study was to determine the relationship between total antioxidant capacity (TAC) from diet and supplements and prostate cancer aggressiveness among 855 African Americans (AA) and 945 European Americans (EA) in the North Carolina-Louisiana Prostate Cancer Project (PCaP). Cases were classified as either high aggressive, low aggressive, or intermediate aggressive. TAC was calculated from the vitamin C equivalent antioxidant capacity of 42 antioxidants measured via food frequency questionnaire. EA reported greater dietary TAC from diet and supplements combined (P < 0.0001). In both minimally and fully adjusted logistic regression models, TAC from diet and supplements combined was associated with a reduced odds of high aggressive prostate cancer in all men, AA and EA: odds ratios for highest vs. lowest level (>1500 vs. <500 mg vitamin C equivalent/day): 0.31 [95% confidence interval (CI): 0.15, 0.67; P-trend < 0.01], 0.28 (95% CI: 0.08, 0.96; P-trend < 0.001), and 0.36 (95% CI: 0.15, 0.86; P-trend = 0.58), respectively. These associations did not appear to differ between AA and EA. These data suggest that greater intake of antioxidants is associated with less aggressive prostate cancer. Additional research is needed to confirm these results and determine the underlying mechanisms.
AB - The purpose of this study was to determine the relationship between total antioxidant capacity (TAC) from diet and supplements and prostate cancer aggressiveness among 855 African Americans (AA) and 945 European Americans (EA) in the North Carolina-Louisiana Prostate Cancer Project (PCaP). Cases were classified as either high aggressive, low aggressive, or intermediate aggressive. TAC was calculated from the vitamin C equivalent antioxidant capacity of 42 antioxidants measured via food frequency questionnaire. EA reported greater dietary TAC from diet and supplements combined (P < 0.0001). In both minimally and fully adjusted logistic regression models, TAC from diet and supplements combined was associated with a reduced odds of high aggressive prostate cancer in all men, AA and EA: odds ratios for highest vs. lowest level (>1500 vs. <500 mg vitamin C equivalent/day): 0.31 [95% confidence interval (CI): 0.15, 0.67; P-trend < 0.01], 0.28 (95% CI: 0.08, 0.96; P-trend < 0.001), and 0.36 (95% CI: 0.15, 0.86; P-trend = 0.58), respectively. These associations did not appear to differ between AA and EA. These data suggest that greater intake of antioxidants is associated with less aggressive prostate cancer. Additional research is needed to confirm these results and determine the underlying mechanisms.
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U2 - 10.1080/01635581.2016.1134596
DO - 10.1080/01635581.2016.1134596
M3 - Article
C2 - 26847416
AN - SCOPUS:84958049148
SN - 0163-5581
VL - 68
SP - 214
EP - 224
JO - Nutrition and Cancer
JF - Nutrition and Cancer
IS - 2
ER -