TY - JOUR
T1 - Dietary antioxidants and prostate cancer
T2 - A review
AU - Vance, Terrence M.
AU - Su, Joseph
AU - Fontham, Elizabeth T.H.
AU - Koo, Sung I.
AU - Chun, Ock K.
N1 - Funding Information:
This article was supported by the NIH Cancer Epidemiology Small Grant #1R03CA159421-01A1.
PY - 2013/8/1
Y1 - 2013/8/1
N2 - Prostate cancer is the most common noncutaneous cancer in men in the United States. Several studies have examined the relationship between prostate cancer and antioxidants; however, the results of these studies are inconsistent. This article provides a systematic review of studies on prostate cancer and antioxidant intake from diet and supplements. Tea and coffee appear to offer protection against advanced prostate cancer. Different forms of vitamin E appear to exert different effects on prostate cancer, with alpha-tocopherol potentially increasing and gamma-tocopherol potentially decreasing risk of the disease. There is no strong evidence for a beneficial effect of selenium, vitamin C, or beta-carotene, whereas lycopene appears to be negatively associated with risk of the disease. The effect of dietary antioxidants on prostate cancer remains undefined and inconclusive, with different antioxidants affecting prostate cancer risk differentially. Further studies are needed to clarify the relationship between antioxidants and prostate cancer risk and to delineate the underlying mechanisms.
AB - Prostate cancer is the most common noncutaneous cancer in men in the United States. Several studies have examined the relationship between prostate cancer and antioxidants; however, the results of these studies are inconsistent. This article provides a systematic review of studies on prostate cancer and antioxidant intake from diet and supplements. Tea and coffee appear to offer protection against advanced prostate cancer. Different forms of vitamin E appear to exert different effects on prostate cancer, with alpha-tocopherol potentially increasing and gamma-tocopherol potentially decreasing risk of the disease. There is no strong evidence for a beneficial effect of selenium, vitamin C, or beta-carotene, whereas lycopene appears to be negatively associated with risk of the disease. The effect of dietary antioxidants on prostate cancer remains undefined and inconclusive, with different antioxidants affecting prostate cancer risk differentially. Further studies are needed to clarify the relationship between antioxidants and prostate cancer risk and to delineate the underlying mechanisms.
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U2 - 10.1080/01635581.2013.806672
DO - 10.1080/01635581.2013.806672
M3 - Review article
C2 - 23909722
AN - SCOPUS:84882408722
SN - 0163-5581
VL - 65
SP - 793
EP - 801
JO - Nutrition and Cancer
JF - Nutrition and Cancer
IS - 6
ER -