Dextromethorphan for treatment of complex partial seizures

R. S. Fisher; B. J. Cysyk; R. P. Lesser; M. J. Pontecorvo; J. T. Ferkany; P. R. Schwerdt; J. Hart; B. Gordon

doi:10.1212/wnl.40.3_part_1.547

Dextromethorphan for treatment of complex partial seizures

R. S. Fisher, B. J. Cysyk, R. P. Lesser, M. J. Pontecorvo, J. T. Ferkany, P. R. Schwerdt, J. Hart, B. Gordon

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Abstract

We performed a double-blind, crossover, add-on study of the antitussive agent dextromethorphan (DM 120 mg/d) as therapy for seizures on 9 patients suffering from severe complex partial seizures. DM had no significant influence on key laboratory values, nor on anticonvulsant drug levels. Side effects were negligible. Complex partial seizure frequency increased 25&percnt; during the DM arm of the study, although this increase was not clinically significant.

Original language	English (US)
Pages (from-to)	547-549
Number of pages	3
Journal	Neurology
Volume	40
Issue number	3
DOIs	https://doi.org/10.1212/wnl.40.3_part_1.547
State	Published - Mar 1990

ASJC Scopus subject areas

Clinical Neurology

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10.1212/wnl.40.3_part_1.547

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AU - Cysyk, B. J.

AU - Lesser, R. P.

AU - Pontecorvo, M. J.

AU - Ferkany, J. T.

AU - Schwerdt, P. R.

AU - Hart, J.

AU - Gordon, B.

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Dextromethorphan for treatment of complex partial seizures

Abstract

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