Dexamethasone Therapy for Bacterial Meningitis

S. X. Skapek; M. G. Ottolini; P. L. Havens; K. J. Kelly; G. M. Hoffman; S. E. Day; T. B. Rice; K. J. Wendelberger; M. J. Chusid; D. G. Maki; H. M. Feder; G. H. McCracken; M. H. Lebel; A. L. Smith

doi:10.1056/NEJM198902163200713

Dexamethasone Therapy for Bacterial Meningitis

S. X. Skapek, M. G. Ottolini, P. L. Havens, K. J. Kelly, G. M. Hoffman, S. E. Day, T. B. Rice, K. J. Wendelberger, M. J. Chusid, D. G. Maki, H. M. Feder, G. H. McCracken, M. H. Lebel, A. L. Smith

Research output: Contribution to journal › Letter › peer-review

6 Scopus citations

Abstract

To the Editor: In their report of a prospective trial of corticosteroids as adjunctive therapy for bacterial meningitis, Lebel et al. (Oct. 13 issue)¹ concluded that dexamethasone “had a significantly beneficial effect on the inflammatory profile of the cerebrospinal fluid in the first 24 hours of treatment and also on hearing.” On the basis of the reported data, such a conclusion is not entirely accurate. When the results of their two studies are analyzed separately, one finds a statistically significant reduction in the number of children who had seizures, subdural effusions, neurologic abnormalities at the time of discharge, or moderate…

Original language	English (US)
Pages (from-to)	463-465
Number of pages	3
Journal	New England Journal of Medicine
Volume	320
Issue number	7
DOIs	https://doi.org/10.1056/NEJM198902163200713
State	Published - Feb 16 1989

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Medicine(all)

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title = "Dexamethasone Therapy for Bacterial Meningitis",

abstract = "To the Editor: In their report of a prospective trial of corticosteroids as adjunctive therapy for bacterial meningitis, Lebel et al. (Oct. 13 issue)1 concluded that dexamethasone “had a significantly beneficial effect on the inflammatory profile of the cerebrospinal fluid in the first 24 hours of treatment and also on hearing.” On the basis of the reported data, such a conclusion is not entirely accurate. When the results of their two studies are analyzed separately, one finds a statistically significant reduction in the number of children who had seizures, subdural effusions, neurologic abnormalities at the time of discharge, or moderate…",

author = "Skapek, {S. X.} and Ottolini, {M. G.} and Havens, {P. L.} and Kelly, {K. J.} and Hoffman, {G. M.} and Day, {S. E.} and Rice, {T. B.} and Wendelberger, {K. J.} and Chusid, {M. J.} and Maki, {D. G.} and Feder, {H. M.} and McCracken, {G. H.} and Lebel, {M. H.} and Smith, {A. L.}",

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doi = "10.1056/NEJM198902163200713",

language = "English (US)",

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T1 - Dexamethasone Therapy for Bacterial Meningitis

AU - Skapek, S. X.

AU - Ottolini, M. G.

AU - Havens, P. L.

AU - Kelly, K. J.

AU - Hoffman, G. M.

AU - Day, S. E.

AU - Rice, T. B.

AU - Wendelberger, K. J.

AU - Chusid, M. J.

AU - Maki, D. G.

AU - Feder, H. M.

AU - McCracken, G. H.

AU - Lebel, M. H.

AU - Smith, A. L.

PY - 1989/2/16

Y1 - 1989/2/16

N2 - To the Editor: In their report of a prospective trial of corticosteroids as adjunctive therapy for bacterial meningitis, Lebel et al. (Oct. 13 issue)1 concluded that dexamethasone “had a significantly beneficial effect on the inflammatory profile of the cerebrospinal fluid in the first 24 hours of treatment and also on hearing.” On the basis of the reported data, such a conclusion is not entirely accurate. When the results of their two studies are analyzed separately, one finds a statistically significant reduction in the number of children who had seizures, subdural effusions, neurologic abnormalities at the time of discharge, or moderate…

AB - To the Editor: In their report of a prospective trial of corticosteroids as adjunctive therapy for bacterial meningitis, Lebel et al. (Oct. 13 issue)1 concluded that dexamethasone “had a significantly beneficial effect on the inflammatory profile of the cerebrospinal fluid in the first 24 hours of treatment and also on hearing.” On the basis of the reported data, such a conclusion is not entirely accurate. When the results of their two studies are analyzed separately, one finds a statistically significant reduction in the number of children who had seizures, subdural effusions, neurologic abnormalities at the time of discharge, or moderate…

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Dexamethasone Therapy for Bacterial Meningitis

Abstract

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