Device trials in heart failure: A focused summary

Olaf Hedrich, Jonathan Weinstock, Mark Link, Munther Homoud, Mark Estes

Research output: Contribution to journalArticlepeer-review


Despite considerable progress in heart failure management with pharmacologic agents, measures to bring about significant improvements in morbidity and mortality are still needed. Cardiac resynchronization therapy (CRT) is a means to enhance myocardial function by stimulating the failing left ventricle at or near the time of right ventricular activation to synchronize ventricular depolarization. Current data from randomized, controlled trials suggest that CRT benefits patients with moderate to severe heart failure and have shown that this therapy significantly reduces mortality and hospital admissions in this group. In addition to CRT, implantable cardioverter-defibrillators have been evaluated in heart failure patients with significantly reduced left ventricular function and have been shown to reduce mortality from sudden cardiac death. This article summarizes recent device trials and discusses how best to apply their results to clinical practice.

Original languageEnglish (US)
Pages (from-to)S21-S31
JournalReviews in Cardiovascular Medicine
Issue numberSUPPL. 2
StatePublished - Jun 1 2005


  • Biventricular pacing
  • Cardiac resynchronization therapy
  • Heart failure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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