Development of a real-time spectral imaging system using in-site micro-LED-based illumination and high-speed micro-camera for endoscopic applications

Naeeme Modir, Maysam Shahedi, James Dormer, Baowei Fei

Research output: Chapter in Book/Report/Conference proceedingConference contribution


We designed a compact, real-time LED-based endoscopic imaging system for the detection of various diseases including cancer. In gastrointestinal applications, conventional endoscopy cannot reliably differentiate tumor from normal tissue. Current hyperspectral imaging systems are too slow to be used for real-time endoscopic applications. We are investigating real-time spectral imaging for different tissue types. Our objective is to develop a catheter for real-time hyperspectral gastrointestinal endoscopy. The endoscope uses multiple wavelengths within UV, visible, and IR light spectra generated by a micro-LED array. We capture images with a monochrome micro camera, which is cost-effective and smaller than the current hyperspectral imagers. A wireless transceiver sends the captured images to a workstation for further processing, such as tumor detection. The spatial resolution of the system is defined by camera resolution and the distance to the object, while the number of LEDs in the multi-wavelength light source determines the spectral resolution. To investigate the properties and the limitations of our high-speed spectral imaging approach, we designed a prototype system. We conducted two experiments to measure the optimal forward voltages and lighting duration of the LEDs. These factors affect the maximum feasible imaging rate and resolution. The lighting duration of each LED can be shorter than 10 ms while producing an image with a high signal-to-noise ratio and no illumination interference. These results support the idea of using a high-speed camera and an LED-array for real-time hyperspectral endoscopic imaging.

Original languageEnglish (US)
Title of host publicationHigh-Speed Biomedical Imaging and Spectroscopy VI
EditorsKevin K. Tsia, Keisuke Goda
ISBN (Electronic)9781510641433
StatePublished - 2021
EventHigh-Speed Biomedical Imaging and Spectroscopy VI 2021 - Virtual, Online, United States
Duration: Mar 6 2021Mar 11 2021

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceHigh-Speed Biomedical Imaging and Spectroscopy VI 2021
Country/TerritoryUnited States
CityVirtual, Online


  • Multispectral imaging (MSI), Hyperspectral imaging (HSI), LED array, monochrome camera, FPGA, cancer, wireless transceiver, and gastrointestinal endoscope

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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