Deuterium metabolic imaging in the human brain at 9.4 Tesla with high spatial and temporal resolution

Loreen Ruhm; Nikolai Avdievich; Theresia Ziegs; Armin M. Nagel; Henk M. De Feyter; Robin A. de Graaf; Anke Henning

doi:10.1016/j.neuroimage.2021.118639

Deuterium metabolic imaging in the human brain at 9.4 Tesla with high spatial and temporal resolution

Loreen Ruhm, Nikolai Avdievich, Theresia Ziegs, Armin M. Nagel, Henk M. De Feyter, Robin A. de Graaf, Anke Henning

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Purpose: To present first highly spatially resolved deuterium metabolic imaging (DMI) measurements of the human brain acquired with a dedicated coil design and a fast chemical shift imaging (CSI) sequence at an ultrahigh field strength of B₀ = 9.4 T. ²H metabolic measurements with a temporal resolution of 10 min enabled the investigation of the glucose metabolism in healthy human subjects. Methods: The study was performed with a double-tuned coil with 10 TxRx channels for ¹H and 8TxRx/2Rx channels for ²H and an Ernst angle 3D CSI sequence with a nominal spatial resolution of 2.97 ml and a temporal resolution of 10 min. Results: The metabolism of [6,6′-²H₂]-labeled glucose due to the TCA cycle could be made visible in high resolution metabolite images of deuterated water, glucose and Glx over the entire human brain. Conclusion: X-nuclei MRSI as DMI can highly benefit from ultrahigh field strength enabling higher temporal and spatial resolutions.

Original language	English (US)
Article number	118639
Journal	NeuroImage
Volume	244
DOIs	https://doi.org/10.1016/j.neuroimage.2021.118639
State	Published - Dec 1 2021

Keywords

9.4 Tesla
DMI
Deuterium
Human brain
Oral glucose administration
TCA cycle

ASJC Scopus subject areas

Neurology
Cognitive Neuroscience

Access to Document

10.1016/j.neuroimage.2021.118639

Cite this

@article{c7cbd04ce7bf416399a8c8f8d47fc180,

title = "Deuterium metabolic imaging in the human brain at 9.4 Tesla with high spatial and temporal resolution",

abstract = "Purpose: To present first highly spatially resolved deuterium metabolic imaging (DMI) measurements of the human brain acquired with a dedicated coil design and a fast chemical shift imaging (CSI) sequence at an ultrahigh field strength of B0 = 9.4 T. 2H metabolic measurements with a temporal resolution of 10 min enabled the investigation of the glucose metabolism in healthy human subjects. Methods: The study was performed with a double-tuned coil with 10 TxRx channels for 1H and 8TxRx/2Rx channels for 2H and an Ernst angle 3D CSI sequence with a nominal spatial resolution of 2.97 ml and a temporal resolution of 10 min. Results: The metabolism of [6,6′-2H2]-labeled glucose due to the TCA cycle could be made visible in high resolution metabolite images of deuterated water, glucose and Glx over the entire human brain. Conclusion: X-nuclei MRSI as DMI can highly benefit from ultrahigh field strength enabling higher temporal and spatial resolutions.",

keywords = "9.4 Tesla, DMI, Deuterium, Human brain, Oral glucose administration, TCA cycle",

author = "Loreen Ruhm and Nikolai Avdievich and Theresia Ziegs and Nagel, {Armin M.} and {De Feyter}, {Henk M.} and {de Graaf}, {Robin A.} and Anke Henning",

note = "Publisher Copyright: {\textcopyright} 2021",

year = "2021",

month = dec,

day = "1",

doi = "10.1016/j.neuroimage.2021.118639",

language = "English (US)",

volume = "244",

journal = "NeuroImage",

issn = "1053-8119",

publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Deuterium metabolic imaging in the human brain at 9.4 Tesla with high spatial and temporal resolution

AU - Ruhm, Loreen

AU - Avdievich, Nikolai

AU - Ziegs, Theresia

AU - Nagel, Armin M.

AU - De Feyter, Henk M.

AU - de Graaf, Robin A.

AU - Henning, Anke

PY - 2021/12/1

Y1 - 2021/12/1

N2 - Purpose: To present first highly spatially resolved deuterium metabolic imaging (DMI) measurements of the human brain acquired with a dedicated coil design and a fast chemical shift imaging (CSI) sequence at an ultrahigh field strength of B0 = 9.4 T. 2H metabolic measurements with a temporal resolution of 10 min enabled the investigation of the glucose metabolism in healthy human subjects. Methods: The study was performed with a double-tuned coil with 10 TxRx channels for 1H and 8TxRx/2Rx channels for 2H and an Ernst angle 3D CSI sequence with a nominal spatial resolution of 2.97 ml and a temporal resolution of 10 min. Results: The metabolism of [6,6′-2H2]-labeled glucose due to the TCA cycle could be made visible in high resolution metabolite images of deuterated water, glucose and Glx over the entire human brain. Conclusion: X-nuclei MRSI as DMI can highly benefit from ultrahigh field strength enabling higher temporal and spatial resolutions.

AB - Purpose: To present first highly spatially resolved deuterium metabolic imaging (DMI) measurements of the human brain acquired with a dedicated coil design and a fast chemical shift imaging (CSI) sequence at an ultrahigh field strength of B0 = 9.4 T. 2H metabolic measurements with a temporal resolution of 10 min enabled the investigation of the glucose metabolism in healthy human subjects. Methods: The study was performed with a double-tuned coil with 10 TxRx channels for 1H and 8TxRx/2Rx channels for 2H and an Ernst angle 3D CSI sequence with a nominal spatial resolution of 2.97 ml and a temporal resolution of 10 min. Results: The metabolism of [6,6′-2H2]-labeled glucose due to the TCA cycle could be made visible in high resolution metabolite images of deuterated water, glucose and Glx over the entire human brain. Conclusion: X-nuclei MRSI as DMI can highly benefit from ultrahigh field strength enabling higher temporal and spatial resolutions.

KW - 9.4 Tesla

KW - DMI

KW - Deuterium

KW - Human brain

KW - Oral glucose administration

KW - TCA cycle

UR - http://www.scopus.com/inward/record.url?scp=85116883511&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85116883511&partnerID=8YFLogxK

U2 - 10.1016/j.neuroimage.2021.118639

DO - 10.1016/j.neuroimage.2021.118639

M3 - Article

C2 - 34637905

AN - SCOPUS:85116883511

SN - 1053-8119

VL - 244

JO - NeuroImage

JF - NeuroImage

M1 - 118639

ER -

Deuterium metabolic imaging in the human brain at 9.4 Tesla with high spatial and temporal resolution

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this