TY - JOUR
T1 - Detection of the myo-inositol 4.06-ppm resonance by selective J rewinding
T2 - Application to human prefrontal cortex in vivo
AU - Choi, Changho
AU - Ogilvie, Catherine J.
AU - Malykhin, Nikolai
AU - Ngo, Jennifer T V
AU - Hartfeil, Misha A W
AU - Coupland, Nicholas J.
PY - 2005/12
Y1 - 2005/12
N2 - A new proton NMR single-voxel spectral editing strategy for the rapid measurement of myo-inositol in human brain is proposed. The spectral editing detects the 4.06-ppm, weakly coupled resonance by means of selective J rewinding. An 84.6-ms-long quadruple-resonance selective 180° radiofrequency pulse, implemented within an adiabatic-refocused localization sequence, induces an in-phase triplet at 4.06 ppm, while eliminating the contribution from creatine, phosphorylethanolamine, lactate, and serine in this spectral region. The myo-inositol concentration in human prefrontal cortex is estimated to be 5.7 ± 0.9 μmol/g (mean ± SD, n = 7), with reference to NAA at 10 μmol/g.
AB - A new proton NMR single-voxel spectral editing strategy for the rapid measurement of myo-inositol in human brain is proposed. The spectral editing detects the 4.06-ppm, weakly coupled resonance by means of selective J rewinding. An 84.6-ms-long quadruple-resonance selective 180° radiofrequency pulse, implemented within an adiabatic-refocused localization sequence, induces an in-phase triplet at 4.06 ppm, while eliminating the contribution from creatine, phosphorylethanolamine, lactate, and serine in this spectral region. The myo-inositol concentration in human prefrontal cortex is estimated to be 5.7 ± 0.9 μmol/g (mean ± SD, n = 7), with reference to NAA at 10 μmol/g.
KW - Human brain
KW - Myo-inositol (ml) 4.06 ppm resonance
KW - Prefrontal cortex
KW - Quadruple-resonance selective
KW - Selective J rewinding
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U2 - 10.1002/mrm.20688
DO - 10.1002/mrm.20688
M3 - Article
C2 - 16215961
AN - SCOPUS:28444458489
SN - 0740-3194
VL - 54
SP - 1536
EP - 1540
JO - Magnetic Resonance in Medicine
JF - Magnetic Resonance in Medicine
IS - 6
ER -