Detecting and defining hypothyroidism after hemithyroidectomy

Hannah G. Piper, Samuel P. Bugis, Graeme E. Wilkins, Blair A.M. Walker, Sam Wiseman, Christopher R. Baliski, Kim Swartz

Research output: Contribution to journalArticlepeer-review

55 Scopus citations


Background: The incidence of hypothyroidism after hemithyroidectomy for benign thyroid disease remains uncertain. This study examines the incidence, natural history, and the factors contributing to hypothyroidism after hemithyroidectomy. Methods: A retrospective review of patients undergoing hemithyroidectomy over 37 months was performed. The incidence of postoperative hypothyroidism was based on thyrotropin values and clinical symptoms. The relationship between hypothyroidism and lymphocytic infiltration of the removed gland was investigated using stepwise logistic regression. Results: Twelve of 66 patients (18%) became biochemically hypothyroid postoperatively. Four of the 12 patients (33%) subsequently became euthyroid without intervention. Of the remaining 8 patients, 4 (50%) had significant lymphocytic infiltration in the resected gland compared with 10 (19%) of the 54 euthyroid patients. Lymphocytic infiltration was associated with hypothyroidism but was age dependent. Conclusions: A minority of patients become hypothyroid after hemithyroidectomy. Some patients with biochemical hypothyroidism will become euthyroid without intervention. The impact of lymphocytic infiltrate on hypothyroidism after hemithyroidectomy is age dependent.

Original languageEnglish (US)
Pages (from-to)587-591
Number of pages5
JournalAmerican journal of surgery
Issue number5 SPEC. ISS.
StatePublished - May 2005


  • Follow-up
  • Hemithyroidectomy
  • Hypothyroidism
  • Lymphocytic infiltration

ASJC Scopus subject areas

  • Surgery


Dive into the research topics of 'Detecting and defining hypothyroidism after hemithyroidectomy'. Together they form a unique fingerprint.

Cite this