DETANONOate is a potent chemo\radio-sensitizing agent in colon and colorectal cancers as assessed in in vitro and in vivo established tumor xenografts

Medicine & Life Sciences

• 2,2'-(hydroxynitrosohydrazono)bis-ethanamine 100%
• Radio 58%
• Colonic Neoplasms 51%
• Heterografts 51%
• Colorectal Neoplasms 45%
• In Vitro Techniques 25%
• Nitric Oxide 23%
• Neoplasms 18%
• diazeniumdiolate 12%
• Up-Regulation 10%
• Apoptosis Inducing Factor 10%
• HT29 Cells 8%
• Apoptosis 8%
• Nitric Oxide Donors 8%
• SCID Mice 8%
• Ionizing Radiation 7%
• Rectal Neoplasms 7%
• Combination Drug Therapy 7%
• Antineoplastic Agents 6%
• Tumor Burden 6%
• Nude Mice 6%
• Cisplatin 6%
• Therapeutics 5%
• Radiotherapy 4%
• Drug Therapy 4%
• Growth 3%
• Pharmaceutical Preparations 2%

Chemical Compounds

• Radiation Sensitizing Agent 96%
• Nitric Oxide 54%
• Sensitizing 47%
• Rectal 28%
• Nitric Oxide Donor 26%
• Ionizing Radiation 23%
• Percent Reduction 22%
• Cisplatin 20%
• Reduction 17%
• Antineoplastic Agent 16%
• Resistance 11%