Design, synthesis, characterization, and biological evaluation of triazine dendrimers bearing paclitaxel using ester and ester/disulfide linkages

Medicine & Life Sciences

• Triazines 87%
• Dendrimers 76%
• Disulfides 59%
• Esters 57%
• Paclitaxel 56%
• N-hydroxysuccinimide 22%
• glutaric anhydride 15%
• cyanuric chloride 13%
• trimethylenediamine 12%
• Cystamine 11%
• Acylation 9%
• Dithiothreitol 8%
• PC-3 Cells 8%
• Ethylene Glycol 8%
• Succinic Acid 8%
• Proton Magnetic Resonance Spectroscopy 8%
• Ether 7%
• Hydroxyl Radical 7%
• Acetic Acid 7%
• Amines 7%
• Spectrum Analysis 6%
• Toxicology 6%
• Inhibitory Concentration 50 6%
• Glutathione 6%
• Mass Spectrometry 6%
• Molecular Weight 5%
• Kidney 3%
• Pharmaceutical Preparations 2%
• Neoplasms 2%

Chemical Compounds

• Paclitaxel 67%
• Triazine 61%
• Dendrimer 55%
• Disulfide 45%
• Ester 34%
• Elimination Half-Life 10%
• Cystamine 9%
• Cyanuric Chloride 9%
• Succinic Acid 7%
• Clearance 7%
• Acylation 6%
• Primary Amine 6%
• Bioassay 6%
• Glutathione 6%
• 1H NMR Spectroscopy 5%
• Poly(ethylene Glycol) 5%
• Acetic Acid 5%
• Weight 3%
• Drug 3%

Engineering & Materials Science

• Dendrimers 100%
• Esters 60%
• Polyethylene glycols 53%
• Acylation 13%
• Glutathione 12%
• Nuclear magnetic resonance spectroscopy 10%
• Cytotoxicity 10%
• Acetic acid 9%
• Mass spectrometry 8%
• Amines 8%
• Scaffolds 8%
• Toxicity 8%
• Ethers 8%
• Assays 8%
• Molecular weight 7%
• Tumors 7%
• Acids 6%