Design of the Texas Hepatocellular Carcinoma Consortium Cohort Study

Ziding Feng, Jorge A. Marrero, Saira Khaderi, Amit G. Singal, Fasiha Kanwal, Nicole Loo, Laura Beretta, Jing Ning, Hashem B. El-Serag

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


OBJECTIVES:The Texas Hepatocellular Carcinoma Consortium cohort study investigates risk factors of hepatocellular carcinoma (HCC) and biomarkers for early HCC detection in patients with liver cirrhosis.METHODS:Adult patients with liver cirrhosis are enrolled at 5 clinical centers from 3 cities in Texas, with a target of 5,000 patients. Clinical history, risk factor questionnaires, liver imaging, laboratory data, and blood samples were collected at enrollment and at each 6-month follow-up visit.RESULTS:The primary outcome was the development of HCC. Biomarkers were tested in banked blood samples using prospective specimen collection, retrospective blinded evaluation design.CONCLUSIONS:We describe study design, eligibility criteria, recruitment, study cores, and sample size and analysis considerations.

Original languageEnglish (US)
Pages (from-to)530-532
Number of pages3
JournalAmerican Journal of Gastroenterology
Issue number3
StatePublished - Mar 1 2019

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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