Dendritic cells: Controllers of the immune system and a new promise for immunotherapy

Jacques Banchereau; Sophie Paczesny; Patrick Blanco; Lynda Bennett; Virginia Pascual; Joseph Fay; A. Karolina Palucka

doi:10.1111/j.1749-6632.2003.tb06047.x

Dendritic cells: Controllers of the immune system and a new promise for immunotherapy

Jacques Banchereau, Sophie Paczesny, Patrick Blanco, Lynda Bennett, Virginia Pascual, Joseph Fay, A. Karolina Palucka

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

The immune system is controlled by dendritic cells (DCs). Just as lymphocytes comprise different subsets, DCs comprise several subsets that differentially control lymphocyte function. In humans, the myeloid pathway includes Langerhans cells (LCs) and interstitial DCs (intDCs). While both subsets produce IL-12, only intDCs make IL-10 and induce B cell differentiation. Another pathway includes plasmacytoid DCs, which promptly secrete large amounts of IFN-α/β upon viral encounter. Thus, insights into in vivo DC functions are important to understand the launching and modulation of immunity.

Original language	English (US)
Pages (from-to)	180-187
Number of pages	8
Journal	Annals of the New York Academy of Sciences
Volume	987
DOIs	https://doi.org/10.1111/j.1749-6632.2003.tb06047.x
State	Published - Jan 1 2003

Keywords

Dendritic cells
Immunotherapy
Interstitial DCs
Langerhans cells
T cells

ASJC Scopus subject areas

Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
History and Philosophy of Science

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10.1111/j.1749-6632.2003.tb06047.x

Cite this

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title = "Dendritic cells: Controllers of the immune system and a new promise for immunotherapy",

abstract = "The immune system is controlled by dendritic cells (DCs). Just as lymphocytes comprise different subsets, DCs comprise several subsets that differentially control lymphocyte function. In humans, the myeloid pathway includes Langerhans cells (LCs) and interstitial DCs (intDCs). While both subsets produce IL-12, only intDCs make IL-10 and induce B cell differentiation. Another pathway includes plasmacytoid DCs, which promptly secrete large amounts of IFN-α/β upon viral encounter. Thus, insights into in vivo DC functions are important to understand the launching and modulation of immunity.",

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AU - Banchereau, Jacques

AU - Paczesny, Sophie

AU - Blanco, Patrick

AU - Bennett, Lynda

AU - Pascual, Virginia

AU - Fay, Joseph

AU - Palucka, A. Karolina

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AB - The immune system is controlled by dendritic cells (DCs). Just as lymphocytes comprise different subsets, DCs comprise several subsets that differentially control lymphocyte function. In humans, the myeloid pathway includes Langerhans cells (LCs) and interstitial DCs (intDCs). While both subsets produce IL-12, only intDCs make IL-10 and induce B cell differentiation. Another pathway includes plasmacytoid DCs, which promptly secrete large amounts of IFN-α/β upon viral encounter. Thus, insights into in vivo DC functions are important to understand the launching and modulation of immunity.

KW - Dendritic cells

KW - Immunotherapy

KW - Interstitial DCs

KW - Langerhans cells

KW - T cells

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Dendritic cells: Controllers of the immune system and a new promise for immunotherapy

Abstract

Keywords

ASJC Scopus subject areas

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