TY - JOUR
T1 - Delayed-interval delivery in multiple gestation pregnancies
T2 - neonatal mortality, morbidity, and development
AU - Bouey, Nicolas J.
AU - Saha, Shampa
AU - Wilson-Costello, Deanne E.
AU - Rysavy, Matthew A.
AU - Walsh, Michele
AU - Wyckoff, Myra H.
AU - Hibbs, Anna Maria
N1 - Funding Information:
While NICHD staff had input into the study design, conduct, analysis, and manuscript drafting, the comments and views of the authors do not necessarily represent the views of NICHD, the National Institutes of Health, the Department of Health and Human Services, or the U.S. Government. Participating NRN sites collected data and transmitted it to RTI International, the data coordinating center (DCC) for the network, which stored, managed and analyzed the data for this study. On behalf of the NRN, RTI International had full access to all of the data in the study, and with the NRN Center Principal Investigators, takes responsibility for the integrity of the data and accuracy of the data analysis. We are indebted to our medical and nursing colleagues and the infants and their parents who agreed to take part in this study.
Funding Information:
The National Institutes of Health, the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the National Center for Research Resources, and the National Center for Advancing Translational Sciences provided grant support for the Neonatal Research Network’s Generic Database and Follow-up Studies through cooperative agreements. The authors have no financial relationships relevant to this article to disclose. Parts of this work were presented at the 2020 Pediatric Academic Societies meeting and the 2020 American Academy of Pediatrics meeting.
Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2022/12
Y1 - 2022/12
N2 - Objective: Delayed-interval delivery (DID) is the delivery of the first fetus in a multiple gestation pregnancy without prompt delivery of the remaining fetus(es). We aimed to assess infant outcomes of DID. Study design: We performed a retrospective cohort study of infants born 22–28 weeks’ gestation or weighing 401–1500 g. DID was defined as a passage of >24 h between the birth of firstborn and retained infants. Rates of mortality, morbidity, and developmental outcomes were compared within DID multiples, to other multiples not born by DID, and all infants in the Generic Database and follow-up datasets (excluding DID-born). Results: DID-born multiples were younger and smaller than other multiples. Retained infants had no significantly different rates of mortality and morbidities compared to their firstborn counterparts, apart from less bronchopulmonary dysplasia. Conclusions: DID showed no evidence of harm and a potential benefit of decreased bronchopulmonary dysplasia mediated by increased gestational age and birthweight.
AB - Objective: Delayed-interval delivery (DID) is the delivery of the first fetus in a multiple gestation pregnancy without prompt delivery of the remaining fetus(es). We aimed to assess infant outcomes of DID. Study design: We performed a retrospective cohort study of infants born 22–28 weeks’ gestation or weighing 401–1500 g. DID was defined as a passage of >24 h between the birth of firstborn and retained infants. Rates of mortality, morbidity, and developmental outcomes were compared within DID multiples, to other multiples not born by DID, and all infants in the Generic Database and follow-up datasets (excluding DID-born). Results: DID-born multiples were younger and smaller than other multiples. Retained infants had no significantly different rates of mortality and morbidities compared to their firstborn counterparts, apart from less bronchopulmonary dysplasia. Conclusions: DID showed no evidence of harm and a potential benefit of decreased bronchopulmonary dysplasia mediated by increased gestational age and birthweight.
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U2 - 10.1038/s41372-022-01462-x
DO - 10.1038/s41372-022-01462-x
M3 - Article
C2 - 35906282
AN - SCOPUS:85135259252
SN - 0743-8346
VL - 42
SP - 1607
EP - 1614
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 12
ER -