Abstract
Erythrocyte formation occurs throughout life in response to cytokine signaling. We show that microRNA-451 (miR-451) regulates erythropoiesis in vivo. Mice lackingmiR-451 display a reduction in hematrocrit, an erythroid differentiation defect, and ineffective erythropoiesis in response to oxidative stress. 14-3-3ζ, an intracellular regulator of cytokine signaling that is repressed by miR-451, is upregulated in miR-451-/- erythroblasts, and inhibition of 14-3-3ζ rescues their differentiation defect. These findings reveal an essential role of 14-3-3ζ as a mediator of the proerythroid differentiation actions of miR-451, and highlight the therapeutic potential of miR-451 inhibitors.
Original language | English (US) |
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Pages (from-to) | 1614-1619 |
Number of pages | 6 |
Journal | Genes and Development |
Volume | 24 |
Issue number | 15 |
DOIs | |
State | Published - Aug 1 2010 |
Keywords
- 14-3-3ζ
- Antagomir
- Erythroid differentiation
- miR-451
- microRNA-451
- ywhaz
ASJC Scopus subject areas
- Genetics
- Developmental Biology