Defective B cell tolerance in adult (NZB x NZW)F 1 mice

E. A. Goldings, P. L. Cohen, S. F. McFadden, M. Ziff, E. S. Vitetta

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Hapten-specific tolerance was induced in vitro by trinitrophenyl-human gamma globulin (TNP 32HGG) to a comparable degree in B cells from adult autoimmune (NZB X NZW)F 1 (B/W) mice and normal BDF 1, CBA/J, and DBA/1J mice. When a lower epitope density tolerogen (TNP 7HGG) was used, B/W mice were significantly less sensitive than normal mice to the induction of B cell tolerance. This finding of defective B cell tolerance in adult B/W mice is consistent with previous reports that document other B cell abnormalities that may relate to the expression of autoimmune disease.

Original languageEnglish (US)
Pages (from-to)730-733
Number of pages4
JournalJournal of Experimental Medicine
Issue number3
StatePublished - 1980

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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