Deep Brain Stimulation for the Treatment of Hemichorea: Case Series and Literature Review

Zihan Masood; Joseph S. Domino; Antonia Gragg; Kim Burchiel; Michael Kinsman; Vibhash D. Sharma

doi:10.5334/tohm.765

Deep Brain Stimulation for the Treatment of Hemichorea: Case Series and Literature Review

Zihan Masood, Joseph S. Domino, Antonia Gragg, Kim Burchiel, Michael Kinsman, Vibhash D. Sharma

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Background: Hemichorea (HC) and its severe form hemiballismus (HB) are rare movement disorders which can be medically refractory to treatments and may need surgical intervention. Case Report: We report 3 patients with HC-HB who had meaningful clinical improvement with unilateral deep brain stimulation (DBS) of the globus pallidus interna (GPi). We identified 8 prior cases of HC-HB treated with GPi-DBS, and a majority of these patients experienced significant improvement in their symptoms. Discussion: GPi-DBS can be considered in medically refractory HC-HB in carefully selected patients. However, data is limited to small case series and further studies are needed.

Original language	English (US)
Article number	21
Journal	Tremor and Other Hyperkinetic Movements
Volume	13
Issue number	1
DOIs	https://doi.org/10.5334/tohm.765
State	Published - 2023

Keywords

Hemiballismus
deep brain stimulation
hyperkinetic movement disorder

ASJC Scopus subject areas

Clinical Neurology
General Medicine

Access to Document

10.5334/tohm.765

Cite this

@article{8dcc04c435824e34b16765c20404edbc,

title = "Deep Brain Stimulation for the Treatment of Hemichorea: Case Series and Literature Review",

abstract = "Background: Hemichorea (HC) and its severe form hemiballismus (HB) are rare movement disorders which can be medically refractory to treatments and may need surgical intervention. Case Report: We report 3 patients with HC-HB who had meaningful clinical improvement with unilateral deep brain stimulation (DBS) of the globus pallidus interna (GPi). We identified 8 prior cases of HC-HB treated with GPi-DBS, and a majority of these patients experienced significant improvement in their symptoms. Discussion: GPi-DBS can be considered in medically refractory HC-HB in carefully selected patients. However, data is limited to small case series and further studies are needed.",

keywords = "Hemiballismus, deep brain stimulation, hyperkinetic movement disorder",

author = "Zihan Masood and Domino, {Joseph S.} and Antonia Gragg and Kim Burchiel and Michael Kinsman and Sharma, {Vibhash D.}",

note = "Publisher Copyright: {\textcopyright} 2023 The Author(s).",

year = "2023",

doi = "10.5334/tohm.765",

language = "English (US)",

volume = "13",

journal = "Tremor and Other Hyperkinetic Movements",

issn = "2160-8288",

publisher = "Center for Digital Research and Scholarship",

number = "1",

}

TY - JOUR

T1 - Deep Brain Stimulation for the Treatment of Hemichorea

T2 - Case Series and Literature Review

AU - Masood, Zihan

AU - Domino, Joseph S.

AU - Gragg, Antonia

AU - Burchiel, Kim

AU - Kinsman, Michael

AU - Sharma, Vibhash D.

PY - 2023

Y1 - 2023

N2 - Background: Hemichorea (HC) and its severe form hemiballismus (HB) are rare movement disorders which can be medically refractory to treatments and may need surgical intervention. Case Report: We report 3 patients with HC-HB who had meaningful clinical improvement with unilateral deep brain stimulation (DBS) of the globus pallidus interna (GPi). We identified 8 prior cases of HC-HB treated with GPi-DBS, and a majority of these patients experienced significant improvement in their symptoms. Discussion: GPi-DBS can be considered in medically refractory HC-HB in carefully selected patients. However, data is limited to small case series and further studies are needed.

AB - Background: Hemichorea (HC) and its severe form hemiballismus (HB) are rare movement disorders which can be medically refractory to treatments and may need surgical intervention. Case Report: We report 3 patients with HC-HB who had meaningful clinical improvement with unilateral deep brain stimulation (DBS) of the globus pallidus interna (GPi). We identified 8 prior cases of HC-HB treated with GPi-DBS, and a majority of these patients experienced significant improvement in their symptoms. Discussion: GPi-DBS can be considered in medically refractory HC-HB in carefully selected patients. However, data is limited to small case series and further studies are needed.

KW - Hemiballismus

KW - deep brain stimulation

KW - hyperkinetic movement disorder

UR - http://www.scopus.com/inward/record.url?scp=85162739905&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85162739905&partnerID=8YFLogxK

U2 - 10.5334/tohm.765

DO - 10.5334/tohm.765

M3 - Article

C2 - 37332655

AN - SCOPUS:85162739905

SN - 2160-8288

VL - 13

JO - Tremor and Other Hyperkinetic Movements

JF - Tremor and Other Hyperkinetic Movements

IS - 1

M1 - 21

ER -

Deep Brain Stimulation for the Treatment of Hemichorea: Case Series and Literature Review

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this