Decreased Creatine Kinase Activity in Cultured Duchenne Dystrophic Muscle Cells

S. T. Iannaccone; B. Nagy; F. J. Samaha

doi:10.1177/088307388700200103

Decreased Creatine Kinase Activity in Cultured Duchenne Dystrophic Muscle Cells

S. T. Iannaccone, B. Nagy, F. J. Samaha

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3 Scopus citations

Abstract

Muscle cells were cultured from six patients with Duchenne muscular dystrophy and nine normal subjects. Protein and myosin content and pyruvate kinase (PK) activity were similar in normal and Duchenne muscular dystrophy cultures. Creatine kinase (CK) activity was lower in Duchenne muscular dystrophy cultures and the isoenzyme distribution indicated MB-CK was significantly lower, while BB-CK was significantly higher in later Duchenne muscular dystrophy cultures. This abnormal isoenzyme pattern suggested aberrant or impaired maturation of Duchenne muscular dystrophy myotubes in vitro. (J Child Neurol 1987; 2:17-21).

Original language	English (US)
Pages (from-to)	17-21
Number of pages	5
Journal	Journal of child neurology
Volume	2
Issue number	1
DOIs	https://doi.org/10.1177/088307388700200103
State	Published - Jan 1987

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Clinical Neurology

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abstract = "Muscle cells were cultured from six patients with Duchenne muscular dystrophy and nine normal subjects. Protein and myosin content and pyruvate kinase (PK) activity were similar in normal and Duchenne muscular dystrophy cultures. Creatine kinase (CK) activity was lower in Duchenne muscular dystrophy cultures and the isoenzyme distribution indicated MB-CK was significantly lower, while BB-CK was significantly higher in later Duchenne muscular dystrophy cultures. This abnormal isoenzyme pattern suggested aberrant or impaired maturation of Duchenne muscular dystrophy myotubes in vitro. (J Child Neurol 1987; 2:17-21).",

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AB - Muscle cells were cultured from six patients with Duchenne muscular dystrophy and nine normal subjects. Protein and myosin content and pyruvate kinase (PK) activity were similar in normal and Duchenne muscular dystrophy cultures. Creatine kinase (CK) activity was lower in Duchenne muscular dystrophy cultures and the isoenzyme distribution indicated MB-CK was significantly lower, while BB-CK was significantly higher in later Duchenne muscular dystrophy cultures. This abnormal isoenzyme pattern suggested aberrant or impaired maturation of Duchenne muscular dystrophy myotubes in vitro. (J Child Neurol 1987; 2:17-21).

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Decreased Creatine Kinase Activity in Cultured Duchenne Dystrophic Muscle Cells

Abstract

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