Decreased caudate volume in neuroleptic-naive psychotic patients

Matcheri S. Keshavan, David Rosenberg, John A. Sweeney, Jay W. Pettegrew

Research output: Contribution to journalArticlepeer-review

185 Scopus citations


Objective: Previous studies, mostly involving neuroleptic-treated patients, have suggested enlarged basal ganglia size in schizophrenia. The authors sought to examine basal ganglia volume in neuroleptic-naive psychotic patients. Method: Magnetic resonance imaging volumetric studies were conducted in newly diagnosed neuroleptic-naive schizophrenic and non- schizophrenic psychotic patients and in matched healthy comparison subjects. Results: Both patient groups had bilaterally reduced caudate, but not putamen, volumes, compared to the healthy subjects, after adjustment for intracranial volume. Conclusions: Decreases in caudate volume in newly diagnosed psychotic patients may be related to the primary pathophysiology of these disorders; prior observations of increased caudate volume may reflect effects of neuroleptic treatment.

Original languageEnglish (US)
Pages (from-to)774-778
Number of pages5
JournalAmerican Journal of Psychiatry
Issue number6
StatePublished - 1998

ASJC Scopus subject areas

  • Psychiatry and Mental health


Dive into the research topics of 'Decreased caudate volume in neuroleptic-naive psychotic patients'. Together they form a unique fingerprint.

Cite this