Decrease in myosin light chain kinase activity of rabbit fast muscle by chronic stimulation

G. A. Klug, M. E. Houston, J. T. Stullo, D. Pette

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Analysis of myosin light chain kinase (MLCK) activity in tibialis anterior muscles of the rabbit revealed that chronic stimulation at a frequency of 10 Hz for 24 h per day reduced the enzyme activity in a timedependent manner. Since fast twitch muscle contains significantly more myosin light chain kinase than slow twitch muscle, the observed reductions are consistent with the type of fast-to-slow transformation observed for other type-specific muscle characteristics. The present data also indicate that the stimulation-induced decrease in MLCK activity precedes the fast-to-slow conversion of the myosin molecule as judged by pyrophosphate-polyacrylamide gel electrophoresis.

Original languageEnglish (US)
Pages (from-to)352-354
Number of pages3
JournalFEBS Letters
Issue number2
StatePublished - May 12 1986


  • (Skeletal muscle)
  • Chronic stimulation
  • Fast-to-slow conversion
  • Isomyosin
  • Myosin light chain kinase

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


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