TY - JOUR
T1 - Deconstructing the relationship between genetics and race
AU - Bamshad, Michael
AU - Wooding, Stephen
AU - Salisbury, Benjamin A.
AU - Stephens, J. Claiborne
N1 - Funding Information:
We thank S. Guthery and M. Pungliya for technical assistance, T. Frudakis for access to data from DNAPrint Genomics, S. Olson and L. Jorde for discussion, and four anonymous reviewers for comments and criticisms. M.B. and S.W. are supported by the US National Institutes of Health and the National Science Foundation.
PY - 2004/8
Y1 - 2004/8
N2 - The success of many strategies for finding genetic variants that underlie complex traits depends on how genetic variation is distributed among human populations. This realization has intensified the investigation of genetic differences among groups, which are often defined by commonly used racial labels. Some scientists argue that race is an adequate proxy of ancestry, whereas others claim that race belies how genetic variation is apportioned. Resolving this controversy depends on understanding the complicated relationship between race, ancestry and the demographic history of humans. Recent discoveries are helping us to deconstruct this relationship, and provide better guidance to scientists and policy makers.
AB - The success of many strategies for finding genetic variants that underlie complex traits depends on how genetic variation is distributed among human populations. This realization has intensified the investigation of genetic differences among groups, which are often defined by commonly used racial labels. Some scientists argue that race is an adequate proxy of ancestry, whereas others claim that race belies how genetic variation is apportioned. Resolving this controversy depends on understanding the complicated relationship between race, ancestry and the demographic history of humans. Recent discoveries are helping us to deconstruct this relationship, and provide better guidance to scientists and policy makers.
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U2 - 10.1038/nrg1401
DO - 10.1038/nrg1401
M3 - Review article
C2 - 15266342
AN - SCOPUS:3442881708
SN - 1471-0056
VL - 5
SP - 598
EP - 609
JO - Nature Reviews Genetics
JF - Nature Reviews Genetics
IS - 8
ER -