Decoding human gene expression signatures in the brain

Guang Zhong Wang, Genevieve Konopka

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


The evolution of higher cognitive functions in humans is thought to be due, at least in part, to the molecular evolution of gene expression patterns specific to the human brain. In this article, we explore recent and past findings using comparative genomics in human and non-human primate brain to identify these novel human patterns. We suggest additional directions and lines of experimentation that should be taken to improve our understanding of these changes on the human lineage. Finally, we attempt to put into context these genomic changes with biological pheno-types and diseases in humans.

Original languageEnglish (US)
Issue number3
StatePublished - 2013


  • Brain
  • Coexpression
  • Evolution
  • Gene expression
  • Genomics
  • Nervous system

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Genetics


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