@article{3b352c56274348ac90eb43addd30b50e,
title = "Data Sources for Heart Failure Comparative Effectiveness Research",
abstract = "Existing data sources for heart failure research offer advantages and disadvantages for comparative effectiveness research. Clinical registries collect detailed information about disease presentation, treatment, and outcomes on a large number of patients and provide the {"} real-world{"} population that is the hallmark of comparative effectiveness research. Data are not collected longitudinally, however, and follow-up is often limited. Large administrative datasets provide the broadest population coverage with longitudinal outcomes follow-up but lack clinical detail. Linking clinical registries with other databases to assess longitudinal outcomes holds great promise.",
keywords = "Clinical registries, Comparative effectiveness research, Databases, Heart failure research",
author = "Ying Xian and Hammill, {Bradley G.} and Curtis, {Lesley H.}",
note = "Funding Information: The Health Care Cost and Utilization Project, which is sponsored by the Agency for Healthcare Research and Quality, includes the largest collection of longitudinal hospital care data in the United States. 65 The Health Care Cost and Utilization Project includes Nationwide Inpatient Sample (NIS) and State Inpatient Databases (SID). The NIS includes more than 100 clinical and nonclinical data elements for each inpatient stay in approximating a 20% stratified sample of community hospitals in the United States. Information includes patient demographics, admission and discharge status, principal and up to 30 secondary diagnosis codes, principal and secondary procedure codes, admission and discharge status, length of stay, and total charges. The SID contains similar data elements but includes 100% inpatient discharge records in participating states. Both NIS and SID contains hospital identifiers that permit linkage with the AHA Annual Survey data and county identifiers for linkage to the Area Resource File. Work is under way to enhance the clinical content of selected state inpatient databases by incorporating electronic laboratory data, hospital-based electronic pharmacy data, electronic prehospital emergency care data, and birth and death certificates. 66 Commercial claims datasets are also available that contain deidentified, person-specific data on enrollment, clinical utilization, and expenditures across inpatient, outpatient, laboratory, and outpatient pharmacy settings. Thomson Healthcare{\textquoteright}s MarketScan database, for example, includes data from approximately 100 commercial, Medicare supplemental, and Medicaid payers that can be linked to track detailed patient information across sites, types of providers, and over time. 67 The potential for these databases to be useful for CER is evidenced by a recent study comparing the effectiveness of rosuvastatin with that of other statins for the prevention of cardiovascular events. 68 ",
year = "2013",
month = jan,
doi = "10.1016/j.hfc.2012.09.001",
language = "English (US)",
volume = "9",
pages = "1--13",
journal = "Heart Failure Clinics",
issn = "1551-7136",
publisher = "Elsevier Inc.",
number = "1",
}