Abstract
There is a high frequency of tumor recurrence in non-muscle invasive bladder cancer (NMIBC) after transurethral resection and postoperative intravesical chemotherapy, however, the molecular mechanisms leading to the chemoresistance and tumor re-growth remain largely unknown. In this study, we observed a significant decrease of DAB2IP expression in high-grade and recurrent NMIBC specimens, which was negatively correlated with Twist1 expression and predicted a lower recurrence-free survival of patients. Mechanistically, DAB2IP could inhibit the phosphorylation and transactivation of STAT3, and then subsequently suppress the expression of Twist1 and its target gene P-glycoprotein, both of which were crucial for the pirarubicin chemoresistance and tumor re-growth of bladder cancer cells. Overall, this study reveals a new promising biomarker modulating the chemoresistance and tumor recurrence of NMIBC after bladder preservation surgery.
Original language | English (US) |
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Pages (from-to) | 2515-2523 |
Number of pages | 9 |
Journal | Cellular Signalling |
Volume | 27 |
Issue number | 12 |
DOIs | |
State | Published - Dec 1 2015 |
Keywords
- Bladder cancer
- DAB2IP
- P-glycoprotein
- Pirarubicin
- Tumor recurrence
- Twist1
ASJC Scopus subject areas
- Cell Biology