Cutaneous neoplastic manifestations of HIV disease

Cindy Berthelot, Clay J Cockerell

Research output: Chapter in Book/Report/Conference proceedingChapter


DEFINITION/OVERVIEW Kaposi’s sarcoma (KS) is the most frequent neoplastic disorder encountered in human immun - odeficiency virus (HIV)-infected patients, and was first described by Moritz Kaposi in 1872 as ‘idio - pathic, multiple, pigment sarcoma’.1 KS was con - sidered to be a relatively rare, slow-growing malig - nancy, most commonly seen in middle-aged and elderly men. However, this changed in 1981, with Alvin Friedman-Kein’s report of what eventually proved to be HIV-associated (epidemic) KS.1,2 This report described more than 50 previously healthy, young homosexual men with KS involving the lymph nodes, viscera, mucosa, and skin.2 Concurrent lifethreatening opportunistic infections were associated with profound immunosuppression, a syndrome now recognized as acquired immunodeficiency syndrome (AIDS). While the different KS subtypes run different clinical courses, what remains constant are the phenotypic features of the proliferating vascular elements (Table 10).

Original languageEnglish (US)
Title of host publicationCutaneous Manifestations of HIV Disease
PublisherCRC Press
Number of pages16
ISBN (Electronic)9781840766042
ISBN (Print)9781840761429
StatePublished - Jan 1 2012

ASJC Scopus subject areas

  • General Medicine


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