@article{7f385ac04ea54db7bf8725fd0656bcb7,
title = "Current Status and Future Perspectives on Neoadjuvant Therapy in Lung Cancer",
abstract = "This Review Article provides a multi-stakeholder view on the current status of neoadjuvant therapy in lung cancer. Given the success of oncogene-targeted therapy and immunotherapy for patients with advanced lung cancer, there is a renewed interest in studying these agents in earlier disease settings with the opportunity to have an even greater impact on patient outcomes. There are unique opportunities and challenges with the neoadjuvant approach to drug development. To achieve more rapid knowledge turns, study designs, endpoints, and definitions of pathologic response should be standardized and harmonized. Continued dialogue with all stakeholders will be critical to design and test novel induction strategies, which could expedite drug development for patients with early lung cancer who are at high risk for metastatic recurrence.",
keywords = "Induction chemotherapy, Neoadjuvant therapy, Pathologic response, Preoperative therapy, Resectable lung cancer",
author = "Blumenthal, {Gideon M.} and Bunn, {Paul A.} and Chaft, {Jamie E.} and McCoach, {Caroline E.} and Perez, {Edith A.} and Scagliotti, {Giorgio V.} and Carbone, {David P.} and Aerts, {Hugo J.W.L.} and Aisner, {Dara L.} and Jonas Bergh and Berry, {Donald A.} and Anthony Jarkowski and Nicholas Botwood and Cross, {Darren A.E.} and Max Diehn and Drezner, {Nicole L.} and Doebele, {Robert C.} and Blakely, {Collin M.} and Eberhardt, {Wilfried E.E.} and Enriqueta Felip and Luca Gianni and Keller, {Steven P.} and Leavey, {Patrick J.} and Shakun Malik and Francesco Pignatti and Prowell, {Tatiana M.} and Redman, {Mary W.} and Rizvi, {Naiyer A.} and Rafael Rosell and Valerie Rusch and {de Ruysscher}, Dirk and Schwartz, {Lawrence H.} and Rajeshwari Sridhara and Stahel, {Rolf A.} and Stephen Swisher and Taube, {Janis M.} and Travis, {William D.} and Patricia Keegan and Wiens, {Jacinta R.} and Wistuba, {Ignacio I.} and Wynes, {Murry W.} and Hirsch, {Fred R.} and Kris, {Mark G.}",
note = "Publisher Copyright: {\textcopyright} 2018",
year = "2018",
month = dec,
doi = "10.1016/j.jtho.2018.09.017",
language = "English (US)",
volume = "13",
pages = "1818--1831",
journal = "Journal of Thoracic Oncology",
issn = "1556-0864",
publisher = "International Association for the Study of Lung Cancer",
number = "12",
}