Current concepts in diabetic microvascular dysfunction

Javier La Fontaine, Lawrence B. Harkless, Christian E. Davis, Marque A. Allen, Paula K. Shireman

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


Microvascular dysfunction is an important component of the pathologic processes that occur in diabetic foot disease. The endothelial abnormalities observed in patients with diabetes mellitus are poorly understood, and evidence suggests that endothelial dysfunction could be involved in the pathogenesis of diabetic macroangiopathy and microangiopathy. With the advent of insulin replacement in the early 1900s and increased efforts toward metabolic control of diabetes, long-term complications of this disease have become apparent. These late-term complications are primarily disorders of the vascular system. This article reviews the process of microvascular dysfunction and how it may relate to the pathogenesis of diabetic foot problems.

Original languageEnglish (US)
Pages (from-to)245-252
Number of pages8
JournalJournal of the American Podiatric Medical Association
Issue number3
StatePublished - 2006

ASJC Scopus subject areas

  • Podiatry
  • Orthopedics and Sports Medicine


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