Cryptococcal lymphadenitis and massive splenomegaly in an immunocompromised patient

Zafer Ünsal Coskun, Dana Mathews, Paul Weatherall, Daniel Skiest, Orhan K. Öz

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


We report an unusual case of lymphadenitis and splenitis in a hemophiliac with AIDS. Splenomegaly without focal lesions was shown by CT and MRI. A Ga-67 scan demonstrated markedly increased activity in the spleen and increased focal activity in the left supraclavicular region. Cryptococcus neoformans was cultured from blood. A fine needle aspirate of a supraclavicular lymph node revealed budding yeast. After therapy, a repeat gallium scan showed no supraclavicular activity and markedly reduced splenic uptake. Cryptococcal infection should be in the differential diagnosis of markedly increased Ga-67 uptake in splenomegaly and focal lymph node uptake in an immunocompromised patient.

Original languageEnglish (US)
Pages (from-to)314-316
Number of pages3
JournalClinical nuclear medicine
Issue number4
StatePublished - Apr 1 2007


  • AIDS
  • Cryptococcus
  • Ga-67 scintigraphy
  • Lymphadenitis
  • MRI
  • Splenomegaly

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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