Critical lipids link breastfeeding to healthy adipose tissue in infancy and adulthood

Christy M. Gliniak; Philipp E. Scherer

doi:10.1172/JCI128830

Critical lipids link breastfeeding to healthy adipose tissue in infancy and adulthood

Christy M. Gliniak, Philipp E. Scherer

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

The study of beige adipose tissue (BeAT) has recently gained popularity because of its potential as a therapeutic target for the treatment of obesity and other metabolic disorders. While BeAT regulation is well understood in adults, the critical signals regulating BeAT during infant development need to be better defined. The bioactive components in breast milk have been primarily studied in the context of immunity. In this issue of the JCI, Yu and Dilbaz et al. identify how a class of breast milk–specific lipid mediators referred to as alkylglycerols (AKGs) maintain BeAT in infants and prevent the transdifferentiation of BeAT into lipid-storing white adipose tissue (WAT).

Original language	English (US)
Pages (from-to)	2198-2200
Number of pages	3
Journal	Journal of Clinical Investigation
Volume	129
Issue number	6
DOIs	https://doi.org/10.1172/JCI128830
State	Published - Jun 3 2019

ASJC Scopus subject areas

Medicine(all)

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10.1172/JCI128830

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title = "Critical lipids link breastfeeding to healthy adipose tissue in infancy and adulthood",

abstract = "The study of beige adipose tissue (BeAT) has recently gained popularity because of its potential as a therapeutic target for the treatment of obesity and other metabolic disorders. While BeAT regulation is well understood in adults, the critical signals regulating BeAT during infant development need to be better defined. The bioactive components in breast milk have been primarily studied in the context of immunity. In this issue of the JCI, Yu and Dilbaz et al. identify how a class of breast milk–specific lipid mediators referred to as alkylglycerols (AKGs) maintain BeAT in infants and prevent the transdifferentiation of BeAT into lipid-storing white adipose tissue (WAT).",

author = "Gliniak, {Christy M.} and Scherer, {Philipp E.}",

note = "Funding Information: This study was supported by NIH grants R01-DK55758, P01-DK088761, R01- DK099110, and P01-AG051459, as well as by an unrestricted grant from the Novo Nordisk Research Foundation (to PES). CMG is supported by T32-DK007307. Funding Information: This study was supported by NIH grants R01-DK55758, P01-DK088761, R01-DK099110, and P01-AG051459, as well as by an unrestricted grant from the Novo Nordisk Research Foundation (to PES). CMG is supported by T32-DK007307. Publisher Copyright: {\textcopyright} 2019, American Society for Clinical Investigation.",

year = "2019",

month = jun,

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doi = "10.1172/JCI128830",

language = "English (US)",

volume = "129",

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journal = "Journal of Clinical Investigation",

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T1 - Critical lipids link breastfeeding to healthy adipose tissue in infancy and adulthood

AU - Gliniak, Christy M.

AU - Scherer, Philipp E.

N1 - Funding Information: This study was supported by NIH grants R01-DK55758, P01-DK088761, R01- DK099110, and P01-AG051459, as well as by an unrestricted grant from the Novo Nordisk Research Foundation (to PES). CMG is supported by T32-DK007307. Funding Information: This study was supported by NIH grants R01-DK55758, P01-DK088761, R01-DK099110, and P01-AG051459, as well as by an unrestricted grant from the Novo Nordisk Research Foundation (to PES). CMG is supported by T32-DK007307. Publisher Copyright: © 2019, American Society for Clinical Investigation.

PY - 2019/6/3

Y1 - 2019/6/3

N2 - The study of beige adipose tissue (BeAT) has recently gained popularity because of its potential as a therapeutic target for the treatment of obesity and other metabolic disorders. While BeAT regulation is well understood in adults, the critical signals regulating BeAT during infant development need to be better defined. The bioactive components in breast milk have been primarily studied in the context of immunity. In this issue of the JCI, Yu and Dilbaz et al. identify how a class of breast milk–specific lipid mediators referred to as alkylglycerols (AKGs) maintain BeAT in infants and prevent the transdifferentiation of BeAT into lipid-storing white adipose tissue (WAT).

AB - The study of beige adipose tissue (BeAT) has recently gained popularity because of its potential as a therapeutic target for the treatment of obesity and other metabolic disorders. While BeAT regulation is well understood in adults, the critical signals regulating BeAT during infant development need to be better defined. The bioactive components in breast milk have been primarily studied in the context of immunity. In this issue of the JCI, Yu and Dilbaz et al. identify how a class of breast milk–specific lipid mediators referred to as alkylglycerols (AKGs) maintain BeAT in infants and prevent the transdifferentiation of BeAT into lipid-storing white adipose tissue (WAT).

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DO - 10.1172/JCI128830

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SP - 2198

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JO - Journal of Clinical Investigation

JF - Journal of Clinical Investigation

IS - 6

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Critical lipids link breastfeeding to healthy adipose tissue in infancy and adulthood

Abstract

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