cRGD-functionalized polymer micelles for targeted doxorubicin delivery

Norased Nasongkla; Xintao Shuai; Hua Ai; Brent D. Weinberg; John Pink; David A. Boothman; Jinming Gao

doi:10.1002/anie.200460800

cRGD-functionalized polymer micelles for targeted doxorubicin delivery

Norased Nasongkla, Xintao Shuai, Hua Ai, Brent D. Weinberg, John Pink, David A. Boothman, Jinming Gao

Research output: Contribution to journal › Article › peer-review

393 Scopus citations

Abstract

Targeting micelles: Cyclic pentapeptide cRGDfk (red triangles), which targets integrin α_vβ₃, was conjugated to the outer shell of doxorubicin-loaded (red hexagons) polymeric micelles by using a postmicelle modification method. The modified micelles significantly enhanced their internalization (up to 30-fold) by receptor-mediated endocytosis in tumor endothelial cells overexpressing the α_vβ₃ receptor. (Figure presented).

Original language	English (US)
Pages (from-to)	6323-6327
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	43
Issue number	46
DOIs	https://doi.org/10.1002/anie.200460800
State	Published - Nov 26 2004

Keywords

Antitumor agents
Bioorganic chemistry
Drug delivery
Micelles
Peptides

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.200460800

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title = "cRGD-functionalized polymer micelles for targeted doxorubicin delivery",

abstract = "Targeting micelles: Cyclic pentapeptide cRGDfk (red triangles), which targets integrin αvβ3, was conjugated to the outer shell of doxorubicin-loaded (red hexagons) polymeric micelles by using a postmicelle modification method. The modified micelles significantly enhanced their internalization (up to 30-fold) by receptor-mediated endocytosis in tumor endothelial cells overexpressing the αvβ3 receptor. (Figure presented).",

keywords = "Antitumor agents, Bioorganic chemistry, Drug delivery, Micelles, Peptides",

author = "Norased Nasongkla and Xintao Shuai and Hua Ai and Weinberg, {Brent D.} and John Pink and Boothman, {David A.} and Jinming Gao",

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doi = "10.1002/anie.200460800",

language = "English (US)",

volume = "43",

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AU - Nasongkla, Norased

AU - Shuai, Xintao

AU - Ai, Hua

AU - Weinberg, Brent D.

AU - Pink, John

AU - Boothman, David A.

AU - Gao, Jinming

PY - 2004/11/26

Y1 - 2004/11/26

N2 - Targeting micelles: Cyclic pentapeptide cRGDfk (red triangles), which targets integrin αvβ3, was conjugated to the outer shell of doxorubicin-loaded (red hexagons) polymeric micelles by using a postmicelle modification method. The modified micelles significantly enhanced their internalization (up to 30-fold) by receptor-mediated endocytosis in tumor endothelial cells overexpressing the αvβ3 receptor. (Figure presented).

AB - Targeting micelles: Cyclic pentapeptide cRGDfk (red triangles), which targets integrin αvβ3, was conjugated to the outer shell of doxorubicin-loaded (red hexagons) polymeric micelles by using a postmicelle modification method. The modified micelles significantly enhanced their internalization (up to 30-fold) by receptor-mediated endocytosis in tumor endothelial cells overexpressing the αvβ3 receptor. (Figure presented).

KW - Antitumor agents

KW - Bioorganic chemistry

KW - Drug delivery

KW - Micelles

KW - Peptides

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M3 - Article

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

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ER -

cRGD-functionalized polymer micelles for targeted doxorubicin delivery

Abstract

Keywords

ASJC Scopus subject areas

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